Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239976264> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4239976264 abstract "Foot process effacement is an important feature of early diabetic nephropathy (DN) which is closely related to the development of albuminuria. Under certain nephrotic conditions, the integrity and function of the glomerular slit diaphragm (SD) structure were impaired and replaced by the tight junction (TJ) structure, resulting in so-called SD-TJ transition, which could partially explain the effacement of foot processes at the molecular level. However, the mechanism underlying the SD-TJ transition has not been described in DN. Here, we demonstrated that impaired autophagic flux blocked p62 mediated degradation of ZO-1 (TJ protein) and promoted podocytes injury via activation of caspase 3 and caspase 8. Interestingly, the expression of VDR in podocytes was decreased under diabetic condition which impaired autophagic flux through down-regulating Atg3. Of note, we also found that VDR abundance was negatively associated with impaired autophagic flux and SD-TJ transition in the glomeruli from human renal biopsy samples with DN. Furthermore, VDR activation improved autophagic flux and attenuated SD-TJ transition in the glomeruli of diabetic animal models. In conclusion, our data provided the novel insight that VDR/Atg3 axis deficiency resulted in SD-TJ transition and foot processes effacement via blocking p62-mediated autophagy pathway in DN.<br>" @default.
- W4239976264 created "2022-05-12" @default.
- W4239976264 creator A5006646786 @default.
- W4239976264 creator A5010557940 @default.
- W4239976264 creator A5011990731 @default.
- W4239976264 creator A5015102287 @default.
- W4239976264 creator A5020367553 @default.
- W4239976264 creator A5033732336 @default.
- W4239976264 creator A5045094860 @default.
- W4239976264 creator A5050333309 @default.
- W4239976264 creator A5055655640 @default.
- W4239976264 creator A5057748562 @default.
- W4239976264 creator A5058396165 @default.
- W4239976264 creator A5063816415 @default.
- W4239976264 creator A5069766932 @default.
- W4239976264 date "2021-08-10" @default.
- W4239976264 modified "2023-10-14" @default.
- W4239976264 title "VDR/Atg3 Axis Regulates Slit Diaphragm to Tight Junction Transition via p62-mediated Autophagy Pathway in Diabetic Nephropathy" @default.
- W4239976264 doi "https://doi.org/10.2337/figshare.15108672" @default.
- W4239976264 hasPublicationYear "2021" @default.
- W4239976264 type Work @default.
- W4239976264 citedByCount "1" @default.
- W4239976264 countsByYear W42399762642022 @default.
- W4239976264 crossrefType "posted-content" @default.
- W4239976264 hasAuthorship W4239976264A5006646786 @default.
- W4239976264 hasAuthorship W4239976264A5010557940 @default.
- W4239976264 hasAuthorship W4239976264A5011990731 @default.
- W4239976264 hasAuthorship W4239976264A5015102287 @default.
- W4239976264 hasAuthorship W4239976264A5020367553 @default.
- W4239976264 hasAuthorship W4239976264A5033732336 @default.
- W4239976264 hasAuthorship W4239976264A5045094860 @default.
- W4239976264 hasAuthorship W4239976264A5050333309 @default.
- W4239976264 hasAuthorship W4239976264A5055655640 @default.
- W4239976264 hasAuthorship W4239976264A5057748562 @default.
- W4239976264 hasAuthorship W4239976264A5058396165 @default.
- W4239976264 hasAuthorship W4239976264A5063816415 @default.
- W4239976264 hasAuthorship W4239976264A5069766932 @default.
- W4239976264 hasBestOaLocation W42399762641 @default.
- W4239976264 hasConcept C126322002 @default.
- W4239976264 hasConcept C134018914 @default.
- W4239976264 hasConcept C177779419 @default.
- W4239976264 hasConcept C185592680 @default.
- W4239976264 hasConcept C190283241 @default.
- W4239976264 hasConcept C203522944 @default.
- W4239976264 hasConcept C2777146197 @default.
- W4239976264 hasConcept C2779561371 @default.
- W4239976264 hasConcept C2779922275 @default.
- W4239976264 hasConcept C2780091579 @default.
- W4239976264 hasConcept C3018201436 @default.
- W4239976264 hasConcept C55493867 @default.
- W4239976264 hasConcept C555293320 @default.
- W4239976264 hasConcept C71924100 @default.
- W4239976264 hasConcept C86803240 @default.
- W4239976264 hasConcept C95444343 @default.
- W4239976264 hasConceptScore W4239976264C126322002 @default.
- W4239976264 hasConceptScore W4239976264C134018914 @default.
- W4239976264 hasConceptScore W4239976264C177779419 @default.
- W4239976264 hasConceptScore W4239976264C185592680 @default.
- W4239976264 hasConceptScore W4239976264C190283241 @default.
- W4239976264 hasConceptScore W4239976264C203522944 @default.
- W4239976264 hasConceptScore W4239976264C2777146197 @default.
- W4239976264 hasConceptScore W4239976264C2779561371 @default.
- W4239976264 hasConceptScore W4239976264C2779922275 @default.
- W4239976264 hasConceptScore W4239976264C2780091579 @default.
- W4239976264 hasConceptScore W4239976264C3018201436 @default.
- W4239976264 hasConceptScore W4239976264C55493867 @default.
- W4239976264 hasConceptScore W4239976264C555293320 @default.
- W4239976264 hasConceptScore W4239976264C71924100 @default.
- W4239976264 hasConceptScore W4239976264C86803240 @default.
- W4239976264 hasConceptScore W4239976264C95444343 @default.
- W4239976264 hasLocation W42399762641 @default.
- W4239976264 hasLocation W42399762642 @default.
- W4239976264 hasLocation W42399762643 @default.
- W4239976264 hasOpenAccess W4239976264 @default.
- W4239976264 hasPrimaryLocation W42399762641 @default.
- W4239976264 hasRelatedWork W1997736718 @default.
- W4239976264 hasRelatedWork W2296097249 @default.
- W4239976264 hasRelatedWork W2604961095 @default.
- W4239976264 hasRelatedWork W2605526923 @default.
- W4239976264 hasRelatedWork W3032731822 @default.
- W4239976264 hasRelatedWork W3187766412 @default.
- W4239976264 hasRelatedWork W4200433164 @default.
- W4239976264 hasRelatedWork W4239976264 @default.
- W4239976264 hasRelatedWork W4251764486 @default.
- W4239976264 hasRelatedWork W4377142677 @default.
- W4239976264 isParatext "false" @default.
- W4239976264 isRetracted "false" @default.
- W4239976264 workType "article" @default.