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- W4240019076 abstract "Abstract To understand the genotoxicity induced in the liver by silver nanoparticles (AgNPs) and silver ions, an engineered gold nanorod core/silver shell nanostructure (Au@Ag NR) and humanized hepatocyte HepaRG cells were used in this study. The involvement of oxidative stress and cell cycle arrest in the DNA and chromosome damage induced by 0.4 - 20 µg.mL -1 Au@Ag NR were investigated by comet assay, γ-H2AX assay, and micronucleus test. Further, the distribution of Au@Ag NR was analyzed. Our results demonstrated that both Ag + and Au@Ag NR led to DNA cleavage and chromosome damage (clastogenicity) in HepaRG cells, and that the Au@Ag NR retained in the nucleus may further release Ag + , aggravating the damages, which are mainly caused by cell cycle arrest and ROS formation. The results reveal the correlation between the intracellular accumulation, Ag + ion release as well as the potential genotoxicity of AgNPs." @default.
- W4240019076 created "2022-05-12" @default.
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- W4240019076 date "2020-10-16" @default.
- W4240019076 modified "2023-09-26" @default.
- W4240019076 title "Roles of ROS and Cell Cycle Arrest in the Genotoxicity Induced by Gold Nanorod Core/silver Shell Nanostructure " @default.
- W4240019076 doi "https://doi.org/10.21203/rs.3.rs-91925/v1" @default.
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