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• W4240032014 abstract "<sec> <title>BACKGROUND</title> Syrian refugees residing in Germany often develop posttraumatic stress as a result of the Syrian civil war, their escape, and postmigration stressors. At the same time, there is a lack of adequate treatment options. The smartphone-based app Sanadak was developed to provide cognitive behavioral therapy–based self-help in the Arabic language for Syrian refugees with posttraumatic stress. </sec> <sec> <title>OBJECTIVE</title> The aim of this study was to evaluate the effectiveness and cost-effectiveness of the app. </sec> <sec> <title>METHODS</title> In a randomized controlled trial, eligible individuals were randomly allocated to the intervention group (IG; app use) or control group (CG; psychoeducational reading material). Data were collected during structured face-to-face interviews at 3 assessments (preintervention/baseline, postintervention/after 4 weeks, follow-up/after 4 months). Using adjusted mixed-effects linear regression models, changes in posttraumatic stress and secondary outcomes were investigated as intention-to-treat (ITT) and per-protocol (PP) analysis. Cost-effectiveness was evaluated based on adjusted mean total costs, quality-adjusted life years (QALYs), and cost-effectiveness acceptability curves using the net benefit approach. </sec> <sec> <title>RESULTS</title> Of 170 screened individuals (aged 18 to 65 years), 133 were eligible and randomized to the IG (n=65) and CG (n=68). Although there was a pre-post reduction in posttraumatic stress, ITT showed no significant differences between the IG and CG after 4 weeks (Posttraumatic Diagnostic Scale for DSM-5, Diff –0.90, 95% CI –0.24 to 0.47; <i>P</i>=.52) and after 4 months (Diff –0.39, 95% CI –3.24 to 2.46; <i>P</i>=.79). The same was true for PP. Regarding secondary outcomes, ITT indicated a treatment effect for self-stigma: after 4 weeks (Self-Stigma of Mental Illness Scale/SSMIS–stereotype agreement: <i>d</i>=0.86, 95% CI 0.46 to 1.25; stereotype application: <i>d</i>=0.60, 95% CI 0.22 to 0.99) and after 4 months (<i>d</i>=0.52, 95% CI 0.12 to 0.92; <i>d</i>=0.50, 95% CI 0.10 to 0.90), the IG showed significantly lower values in self-stigma than the CG. ITT showed no significant group differences in total costs and QALYs. The probability of cost-effectiveness was 81% for a willingness-to-pay of €0 per additional QALY but decreased with increasing willingness-to-pay. </sec> <sec> <title>CONCLUSIONS</title> Sanadak was not more effective in reducing mild to moderate posttraumatic stress in Syrian refugees than the control condition nor was it likely to be cost-effective. Therefore, Sanadak is not suitable as a standalone treatment. However, as the app usability was very good, no harms detected, and stigma significantly reduced, Sanadak has potential as a bridging aid within a stepped and collaborative care approach. </sec> <sec> <title>CLINICALTRIAL</title> German Clinical Trials Register DRKS00013782; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&amp;TRIAL_ID=DRKS00013782 </sec> <sec> <title>INTERNATIONAL REGISTERED REPORT</title> RR2-10.1186/s12888-019-2110-y </sec>" @default.
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• W4240032014 date "2020-10-06" @default.
• W4240032014 modified "2023-10-14" @default.
• W4240032014 title "A Self-Help App for Syrian Refugees With Posttraumatic Stress (Sanadak): Randomized Controlled Trial (Preprint)" @default.
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• W4240032014 doi "https://doi.org/10.2196/preprints.24807" @default.
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