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- W4240046825 abstract "This chapter discusses a study examining development of antibodies against catecholamines. The presence of antibodies in immunized animals can be demonstrated by a number of immunologic techniques. The radioimmunoassay approach involves the incubation of a constant amount of labeled dopamine with varying dilutions of antiserum and then determining the distribution of radioactivity bound to the antibody. In one study, fat cells were isolated, and free fatty acid analysis was conducted on a chloroform extract. The data shows that the antibody at a dilution of 1:10 inhibited the lipolytic response to norepinephrine by about 85%. If the antibody is diluted 1:100 it loses its ability to inhibit the lipolytic action of 10−6 M norepinephrine. Because these preliminary in vitro studies indicated that the antibody could neutralize some of the biological activities of catecholamines, studies were initiated to determine its effect on rat blood pressure. At low concentrations of the antibody, it fails to exert any effect on blood pressure. However, at higher concentrations, it produces a precipitous fall in blood pressure which returns to the previous level within 1 to 2 min." @default.
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- W4240046825 date "1973-01-01" @default.
- W4240046825 modified "2023-10-18" @default.
- W4240046825 title "DEVELOPMENT OF ANTIBODIES AGAINST CATECHOLAMINES" @default.
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- W4240046825 doi "https://doi.org/10.1016/b978-0-08-017922-3.50061-7" @default.
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