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• W4240060324 abstract "Abstract Background: Wheezing in infancy is very common. RSV infection can cause recurrent wheezing. The aim of this study was to explore the risk factors of recurrent wheezing in children under 3 years of age after RSV infection. Methods： We chose children with initial wheezing before 3 years of age who were hospitalized for medical treatment. Wheezing frequency was determined by follow-up at 1 week, 1 month, 3 months, 6 months, and 1 year. Information such as birth status, age, sex, preterm, mode of delivery, birth order, eczema history, personal allergy history, family allergy history, passive smoking, and place of residence (urban/rural) was collected. Total serum IgE level, serum allergen testing, routine blood tests, C-reactive protein level, procalcitonin level, respiratory pathogens tests, sputum culture, chest radiography or computed tomography were performed in all patients. The correlation between each factor and wheezing recurrence was evaluated. Results: A total of 259 children were included in the study. They were divided into single recurrence, multiple recurrences, and no recurrence groups. There were significant differences between the single recurrence and multiple recurrences groups in terms of personal allergy history, passive smoking, total serum IgE level, age, hospital stay duration, and wheezing duration (p<0.05). The percentage of children with a personal allergy history in the multiple recurrences group was significantly higher than that of children in the single recurrence and no recurrence groups (p=0.031 and 0.008, respectively). The age of children in the multiple recurrences group was significantly lower than that of children in the single recurrence group (p=0.000). The cost of re-hospitalization in the multiple recurrences group was significantly higher than that in the single recurrence and no recurrence groups (p=0.000 and 0.000, respectively). Conclusions: Children with a personal allergy history were more likely to have wheezing episodes. The frequency of wheezing in children under 3 years of age within 1 year of a respiratory syncytial virus infection was related to age. The younger the age at the time of the onset of wheezing, the more wheezing recurrences in the following year." @default.
• W4240060324 created "2022-05-12" @default.
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• W4240060324 date "2020-08-24" @default.
• W4240060324 modified "2023-09-28" @default.
• W4240060324 title "Recurrent wheezing after respiratory syncytial virus infection in children under 3 years of age: a 1-year follow-up study" @default.
• W4240060324 doi "https://doi.org/10.21203/rs.3.rs-59435/v1" @default.
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