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- W4240074032 abstract "The chemical structures of a number of the older antineoplastic agents, such as the anthracyclines or anthraquinones, consist of linear three- or four-ring flat molecules. The mode of action of those drugs was at first ascribed to intercalation. This process involved insertion between DNA base pairs and thus inhibition of the processes mediated by the DNA. It has more recently been found that intercalation is only the first part of the inhibitory process; the cytotoxic effect is due to the inhibition of topoisomerases. The respectable antineoplastic activity of camptothecin generated several programs aimed at modifying the natural product in order to generate analogues with improved physical properties. Topoisomerase II inhibition ranks among the mechanisms by which the flavonoid idronoxil, also known as phenoxodiol, kills cancer cells. Little clinical data is available as the compound seems to have only recently entered clinical trials." @default.
- W4240074032 created "2022-05-12" @default.
- W4240074032 date "2015-03-13" @default.
- W4240074032 modified "2023-09-23" @default.
- W4240074032 title "Topoisomerase Inhibitors" @default.
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- W4240074032 doi "https://doi.org/10.1002/9781118892572.ch4" @default.
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