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- W4240075907 abstract "A study of the induction of broadly neutralizing antibodies (bNAbs) in HIV-infected patients and vaccinated subjects revealed the main criteria for the formation of bNAbs (the duration of exposure to a viral antigen, the effect of the diversity of HIV variants, and the removal of barriers associated with the Env-dependent defense mechanisms of HIV-1). Modified trimers of the HIV-1 envelope protein (Env) exposed on virus-like particles (VLP) have unique properties: they (i) modulate the exposure of binding sites (bs) of the CD4 receptor and co-receptor; (ii) create steric restrictions for contact with bNAbs; (iii) increase the Env presentation density, thus enhancing the immune response; (iv) form stable trimers that do not induce off-target immune responses; and (v) allow additional modifications to their structure and construction of a platform with immunostimulating molecules. Immunization using a heterologous subtype-cross prime–boost regime with modified trimeric Env is capable of inducing somatic hypermutation levels necessary for the formation of bNAbs." @default.
- W4240075907 created "2022-05-12" @default.
- W4240075907 creator A5002124816 @default.
- W4240075907 creator A5033735857 @default.
- W4240075907 date "2017-11-01" @default.
- W4240075907 modified "2023-10-14" @default.
- W4240075907 title "Requirements for the Induction of Broadly Neutralizing Antibodies against HIV-1 by Vaccination" @default.
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