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- W4240085518 abstract "To investigate the effect of preoperative mycophenoiate mofetil (MMF) on allograft survival in a murine corneal transplantation model. Corneal grafting was performed from Brown Norway to Lewis rats. Groups were divided as follows: Rats that received syngeneic or allogeneic grafts without therapy served as controls. MMF treatment was either started 7 days prior to transplantation and continued for 14 postoperative days (POD) or started at the day of corneal grafting until POD 14. MMF (20 mg/kg) administered postoperatively had no significant beneficial effect on corneal graft survival when compared with controls. However, the group receiving 40 mg/kg MMF postoperatively showed a statistically significant prolonged graft survival. A 1-week preoperative administration of 20 mg/kg MMF allowed superior graft survival. Priming the immune system of corneal transplant recipients preoperatively with MMF proved to be a beneficial therapeutic regimen for prolonging corneal allograft survival in rats." @default.
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- W4240085518 date "1999-10-01" @default.
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- W4240085518 title "Beneficial effect of preoperative mycophenoiate mofetil in murine corneal transplantation" @default.
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- W4240085518 doi "https://doi.org/10.1111/j.1432-2277.1999.tb00619.x" @default.
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