FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4240096532> ?p ?o ?g. }

• W4240096532 endingPage "1512" @default.
• W4240096532 startingPage "1511" @default.
• W4240096532 abstract "The patient was a 59-year-old homosexual man, who was first noted to be positive for human immunodeficiency virus (HIV) 3 years earlier. Subsequently, he was diagnosed as having hepatitis B, oral candidiasis, central nervous system toxoplasmosis, and perirectal herpes simplex virus. He owned a cat and a dog. The remainder of his past medical history was noncontributory.The patient was referred to the University Hospital in Madrid, Spain, because of a month-long history of shortness of breath and fatigue. On admission, a chest radiograph showed bilateral interstitial lung infiltrates. His CD4+ T-cell count was less than 200 cells/μL. Diagnostic bronchoscopy was performed, which showed endobronchial lesions consistent with pulmonary Kaposi sarcoma. Microscopic examination revealed numerous macrophages in the submucosa below the bronchial epithelium (Figure 1). This feature was better appreciated by Giemsa stain (Figure 2). Subsequent bone marrow biopsy showed identical images. The diagnosis was confirmed by culture, but speciation was not possible. The patient died shortly thereafter of multiorgan failure. An autopsy was not performed.What is your diagnosis?Visceral leishmaniasis is endemic in certain parts of Southern Europe, so it should be considered in HIV-positive patients living in or traveling to these areas.1–3 For example, 31.5 million people visited Spain in the first half of the year 2000.4 It is interesting to note that a significant travel history may be obtained from patients in cases developing in nonendemic areas.3,5 This issue is further complicated by the occurrence of atypical clinical forms (solitary pulmonary nodule, pleural effusion, endobronchial lesions, etc), which enhance the need for histologic study in this setting.1–3,6,7 The amastigotes are mainly found in skin, liver, gastrointestinal tract, lymph node, and bone marrow specimens.1–3 In this regard, cytologic examination often permits a specific diagnosis, thereby avoiding unnecessary procedures.8 Although Leishmania species have been identified in bronchoalveolar lavage specimens,1,5 diagnosis of visceral leishmaniasis on bronchial biopsies appears to be distinctly uncommon.1–3,9 Intracellular and extracellular Leishmania amastigotes are found below the bronchial epithelium. A recently reported case in an immunocompetent man showed only noncaseating granulomatous inflammation with multinucleated giant cells. The diagnosis was based on a positive polymerase chain reaction. Molecular evidence of Leishmania species was pursued using kinetoplast minicircle DNA-specific primers.9 Although such an approach may be useful in cases with scant evidence of parasites, most leishmaniasis in HIV-positive patients can be diagnosed by histology alone.Differential diagnosis includes other intracellular microorganisms.8 Leishmania species amastigotes are round and exhibit paranuclear bodies (kinetoplasts). Giemsa is the stain of choice. Histoplasma appears as a silver-stained structure with halo effect. Toxoplasma usually affects somatic cells and shows a characteristic crescentic shape. Finally, pathologists should remember that Leishmania species may coexist in the same surgical specimen with other acquired immunodeficiency virus–related diseases (mycobacteriosis, cytomegalovirus infection, Kaposi sarcoma, etc).1,10In summary, we have shown an apparently unique case in which initial diagnosis of visceral leishmaniasis was unexpectedly made on bronchial biopsies. This case illustrates the importance of considering visceral leishmaniasis in HIV-positive patients. Unusual clinical presentations could be promptly diagnosed if histologic diagnosis is performed.We thank the Department of Internal Medicine, “12 de Octubre” University Hospital, Madrid, Spain, for clinical information. We are also grateful to Melchor Baixas, BA, in Economics, for excellent bibliographic help." @default.
• W4240096532 created "2022-05-12" @default.
• W4240096532 creator A5018729076 @default.
• W4240096532 creator A5030742339 @default.
• W4240096532 creator A5072151730 @default.
• W4240096532 date "2001-11-01" @default.
• W4240096532 modified "2023-10-16" @default.
• W4240096532 title "Pathologic Quiz Case: A Patient With Acquired Immunodeficiency Syndrome and Endobronchial Lesions" @default.
• W4240096532 cites W2017432057 @default.
• W4240096532 cites W2018834908 @default.
• W4240096532 cites W2027809993 @default.
• W4240096532 cites W2029049300 @default.
• W4240096532 cites W2045279991 @default.
• W4240096532 cites W2153743322 @default.
• W4240096532 cites W2155481722 @default.
• W4240096532 cites W4239847505 @default.
• W4240096532 cites W948337989 @default.
• W4240096532 doi "https://doi.org/10.5858/2001-125-1511-pqcapw" @default.
• W4240096532 hasPublicationYear "2001" @default.
• W4240096532 type Work @default.
• W4240096532 citedByCount "4" @default.
• W4240096532 countsByYear W42400965322018 @default.
• W4240096532 countsByYear W42400965322022 @default.
• W4240096532 crossrefType "journal-article" @default.
• W4240096532 hasAuthorship W4240096532A5018729076 @default.
• W4240096532 hasAuthorship W4240096532A5030742339 @default.
• W4240096532 hasAuthorship W4240096532A5072151730 @default.
• W4240096532 hasConcept C126322002 @default.
• W4240096532 hasConcept C141071460 @default.
• W4240096532 hasConcept C142724271 @default.
• W4240096532 hasConcept C156662089 @default.
• W4240096532 hasConcept C159654299 @default.
• W4240096532 hasConcept C16005928 @default.
• W4240096532 hasConcept C163764329 @default.
• W4240096532 hasConcept C203014093 @default.
• W4240096532 hasConcept C206179267 @default.
• W4240096532 hasConcept C2775934546 @default.
• W4240096532 hasConcept C2777714996 @default.
• W4240096532 hasConcept C2778996910 @default.
• W4240096532 hasConcept C2779052585 @default.
• W4240096532 hasConcept C2779134260 @default.
• W4240096532 hasConcept C2779382419 @default.
• W4240096532 hasConcept C2779413141 @default.
• W4240096532 hasConcept C2779504383 @default.
• W4240096532 hasConcept C2780007613 @default.
• W4240096532 hasConcept C2780063514 @default.
• W4240096532 hasConcept C2781069245 @default.
• W4240096532 hasConcept C2781137159 @default.
• W4240096532 hasConcept C71924100 @default.
• W4240096532 hasConceptScore W4240096532C126322002 @default.
• W4240096532 hasConceptScore W4240096532C141071460 @default.
• W4240096532 hasConceptScore W4240096532C142724271 @default.
• W4240096532 hasConceptScore W4240096532C156662089 @default.
• W4240096532 hasConceptScore W4240096532C159654299 @default.
• W4240096532 hasConceptScore W4240096532C16005928 @default.
• W4240096532 hasConceptScore W4240096532C163764329 @default.
• W4240096532 hasConceptScore W4240096532C203014093 @default.
• W4240096532 hasConceptScore W4240096532C206179267 @default.
• W4240096532 hasConceptScore W4240096532C2775934546 @default.
• W4240096532 hasConceptScore W4240096532C2777714996 @default.
• W4240096532 hasConceptScore W4240096532C2778996910 @default.
• W4240096532 hasConceptScore W4240096532C2779052585 @default.
• W4240096532 hasConceptScore W4240096532C2779134260 @default.
• W4240096532 hasConceptScore W4240096532C2779382419 @default.
• W4240096532 hasConceptScore W4240096532C2779413141 @default.
• W4240096532 hasConceptScore W4240096532C2779504383 @default.
• W4240096532 hasConceptScore W4240096532C2780007613 @default.
• W4240096532 hasConceptScore W4240096532C2780063514 @default.
• W4240096532 hasConceptScore W4240096532C2781069245 @default.
• W4240096532 hasConceptScore W4240096532C2781137159 @default.
• W4240096532 hasConceptScore W4240096532C71924100 @default.
• W4240096532 hasIssue "11" @default.
• W4240096532 hasLocation W42400965321 @default.
• W4240096532 hasOpenAccess W4240096532 @default.
• W4240096532 hasPrimaryLocation W42400965321 @default.
• W4240096532 hasRelatedWork W1982359598 @default.
• W4240096532 hasRelatedWork W2045749147 @default.
• W4240096532 hasRelatedWork W2130113318 @default.
• W4240096532 hasRelatedWork W2161648435 @default.
• W4240096532 hasRelatedWork W2375677212 @default.
• W4240096532 hasRelatedWork W2414603148 @default.
• W4240096532 hasRelatedWork W2895456192 @default.
• W4240096532 hasRelatedWork W3028991096 @default.
• W4240096532 hasRelatedWork W4292219144 @default.
• W4240096532 hasRelatedWork W4310592836 @default.
• W4240096532 hasVolume "125" @default.
• W4240096532 isParatext "false" @default.
• W4240096532 isRetracted "false" @default.
• W4240096532 workType "article" @default.