Matches in SemOpenAlex for { <https://semopenalex.org/work/W4240167688> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4240167688 endingPage "1883" @default.
- W4240167688 startingPage "1875" @default.
- W4240167688 abstract "MRP8 and MRP14 are two Ca(2+)-binding proteins of the S-100 family expressed by myelomonocytic cells. Both proteins assemble to noncovalently associated complexes in a Ca(2+)-dependent manner. Members of the S-100 family are known to play a role in cytoskeletal- membrane interactions; therefore, we investigated the subcellular distribution of MRP8/MRP14 and their complexes in human monocytes. Using differential centrifugation and subsequent Western blot or enzyme- linked immunosorbent assay analysis, we found that MRP8/MRP14 were almost completely translocated from the cytoplasma to membrane and cytoskeletal structures in a Ca(2+)-dependent manner. Using a cross- linking technique, complexed forms of MRP8/MRP14 were found to be associated with the plasma membrane. Analysis of MRP-transfected L132 cells showed that the MRP8 as well as the MRP14 component of the MRP8/MRP14 complex may independently bind to membrane and cytoskeletal structures. Furthermore, immunogold electron microscopy showed a colocalization of MRP8/MRP14 and the intermediate filament type III protein vimentin in A23187-treated monocytes. Our data indicate that, in analogy to other S-100-like proteins, MRP8 and MRP14 play a role in Ca(2+)-dependent cytoskeletal-membrane interactions. Restriction of MRP8/MRP14 expression to distinct stages of myelomonocytic differentiation suggests that these proteins are involved in highly specific pathways of intracellular signaling in phagocytes." @default.
- W4240167688 created "2022-05-12" @default.
- W4240167688 creator A5011447666 @default.
- W4240167688 creator A5027136315 @default.
- W4240167688 creator A5036233896 @default.
- W4240167688 creator A5063516762 @default.
- W4240167688 creator A5071498197 @default.
- W4240167688 creator A5076078511 @default.
- W4240167688 date "1993-09-15" @default.
- W4240167688 modified "2023-09-27" @default.
- W4240167688 title "MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner" @default.
- W4240167688 doi "https://doi.org/10.1182/blood.v82.6.1875.bloodjournal8261875" @default.
- W4240167688 hasPublicationYear "1993" @default.
- W4240167688 type Work @default.
- W4240167688 citedByCount "5" @default.
- W4240167688 countsByYear W42401676882016 @default.
- W4240167688 countsByYear W42401676882018 @default.
- W4240167688 crossrefType "journal-article" @default.
- W4240167688 hasAuthorship W4240167688A5011447666 @default.
- W4240167688 hasAuthorship W4240167688A5027136315 @default.
- W4240167688 hasAuthorship W4240167688A5036233896 @default.
- W4240167688 hasAuthorship W4240167688A5063516762 @default.
- W4240167688 hasAuthorship W4240167688A5071498197 @default.
- W4240167688 hasAuthorship W4240167688A5076078511 @default.
- W4240167688 hasBestOaLocation W42401676881 @default.
- W4240167688 hasConcept C142669718 @default.
- W4240167688 hasConcept C144647389 @default.
- W4240167688 hasConcept C1491633281 @default.
- W4240167688 hasConcept C168240541 @default.
- W4240167688 hasConcept C190062978 @default.
- W4240167688 hasConcept C41625074 @default.
- W4240167688 hasConcept C55493867 @default.
- W4240167688 hasConcept C78383274 @default.
- W4240167688 hasConcept C86803240 @default.
- W4240167688 hasConcept C95444343 @default.
- W4240167688 hasConceptScore W4240167688C142669718 @default.
- W4240167688 hasConceptScore W4240167688C144647389 @default.
- W4240167688 hasConceptScore W4240167688C1491633281 @default.
- W4240167688 hasConceptScore W4240167688C168240541 @default.
- W4240167688 hasConceptScore W4240167688C190062978 @default.
- W4240167688 hasConceptScore W4240167688C41625074 @default.
- W4240167688 hasConceptScore W4240167688C55493867 @default.
- W4240167688 hasConceptScore W4240167688C78383274 @default.
- W4240167688 hasConceptScore W4240167688C86803240 @default.
- W4240167688 hasConceptScore W4240167688C95444343 @default.
- W4240167688 hasIssue "6" @default.
- W4240167688 hasLocation W42401676881 @default.
- W4240167688 hasOpenAccess W4240167688 @default.
- W4240167688 hasPrimaryLocation W42401676881 @default.
- W4240167688 hasRelatedWork W10578506 @default.
- W4240167688 hasRelatedWork W1605357185 @default.
- W4240167688 hasRelatedWork W1866340627 @default.
- W4240167688 hasRelatedWork W2027176484 @default.
- W4240167688 hasRelatedWork W2031255905 @default.
- W4240167688 hasRelatedWork W2037043660 @default.
- W4240167688 hasRelatedWork W2094162672 @default.
- W4240167688 hasRelatedWork W2271407082 @default.
- W4240167688 hasRelatedWork W2332486747 @default.
- W4240167688 hasRelatedWork W79211704 @default.
- W4240167688 hasVolume "82" @default.
- W4240167688 isParatext "false" @default.
- W4240167688 isRetracted "false" @default.
- W4240167688 workType "article" @default.