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- W4240194311 abstract "Abstract We describe a simple, rapid chromatographic method for separating and quantitatively determining sulfisoxazole and its N4-acetyl metabolite in plasma and urine. A 100-micro L sample of plasma or urine is combined with 200 micro L of a solution containing 12 mg/L of the internal standard, N4-acetylsulfamethoxazole, in absolute methanol and centrifuged to obtain a clear supernatant solution. This solution is then eluted through a 10-micron microparticulate column with a mobile phase of 32/68 (by vol) methanol/sodium acetate buffer (0.01 mol/L, pH 4.7), at a flow rate of 1.2 mL/min. The eluted sompounds are detected by their absorption at 254 nm. We calculated concentration from the peak-height ratios of sulfisoxazole or N4-acetylsulfisoxazole to N4-acetylsulfamethoxazole. The peak-height ratio was linear with concentration in the range 0.05--200 mg/L for both drug and metabolite in plasma and urine. Because this assay can be completed within 30 min of obtaining a blood or urine sample, it should be a valuable tool in clinical drug monitoring and pharmacokinetic studies." @default.
- W4240194311 created "2022-05-12" @default.
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- W4240194311 date "1980-01-01" @default.
- W4240194311 modified "2023-10-16" @default.
- W4240194311 title "High-pressure liquid chromatography of sulfisoxazole and N4-acetylsulfisoxazole in body fluids." @default.
- W4240194311 doi "https://doi.org/10.1093/clinchem/26.1.51" @default.
- W4240194311 hasPublicationYear "1980" @default.
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