Matches in SemOpenAlex for { <https://semopenalex.org/work/W4240241827> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4240241827 abstract "Abstract Background: Early goal-directed therapy (EGDT) using the FloTrac system reportedly decreased mortality, morbidity, and length of stay (LOS) in intensive care unit (ICU) and hospital among high-risk patients undergoing non-cardiac surgery. The objective of this study was to evaluate the efficacy of the FloTrac/EV1000 platform for improving postoperative outcomes in cardiac surgery. Methods: Eighty-six adults undergoing coronary artery bypass graft (CABG) with cardiopulmonary bypass (CPB) were randomized to the EV1000 or Control group. The Control group was managed with standard care to achieve the following goals: mean arterial pressure 65-90 mmHg; central venous pressure 8-12 mmHg; urine output ≥ 0.5 mL/kg/h; oxygen saturation > 95%; and hematocrit 26-30%. The EV1000 group was managed to reach similar goals using information from the FloTrac/EV1000 monitor. The targets were: stroke volume variation (SVV) < 13%; cardiac index (CI) 2.2-4.0 L/min/m 2 ; stroke volume index (SVI) 33‑65 mL/beat/m 2 ; and systemic vascular resistance index (SVRI) 1600‑2500 dynes/s/cm 5 /m 2 . Results: The LOS in ICU of the EV1000 group was significantly shorter (mean difference -29.5 h; 95%CI -17.2 to -41.8, p < 0.001). The mechanical ventilation time was also shorter in the EV1000 group (mean difference -11.3 h; 95%CI -2.7 to -19.9, p = 0.011). The hospital LOS was shorter in the EV1000 group (mean difference -1.1 d; 95%CI -0.1 to -2.1, p =0.038). The EV1000 group received a higher number of inotropic or vasoactive drugs than the Control group in pre-bypass period, but less in post-bypass, postoperative period before transfer to the ICU, and in the ICU. The EV1000 group had less atrial fibrillation with rapid ventricular response, acute respiratory distress syndrome, and acute renal injury. Conclusions: Compared with standard care, intraoperative hemodynamic optimization using the FloTrac/EV1000 platform for the EGDT protocol in patients undergoing CABG with CPB resulted in shorter ventilator time, shorter ICU and hospital LOS, and fewer postoperative complications. The EV1000 group required more fluid and inotropic or vasoactive drugs in the pre-bypass period to optimize SVV, CI, and SVRI and to maintain the target MAP resulting in better myocardium oxygen supply reflected in fewer drugs required during post-bypass, before transfer to, and in, the ICU. Trial registration The study was registered with ClinicalTrials.gov (NCT04292951) on 03/03/2020." @default.
- W4240241827 created "2022-05-12" @default.
- W4240241827 creator A5015406742 @default.
- W4240241827 creator A5042088517 @default.
- W4240241827 creator A5073114768 @default.
- W4240241827 creator A5088426401 @default.
- W4240241827 date "2021-03-10" @default.
- W4240241827 modified "2023-09-26" @default.
- W4240241827 title "Efficacy of Intraoperative Hemodynamic Optimization Using FloTrac/EV1000 Platform for Early Goal-directed Therapy to Improve Postoperative Outcomes in Patients Undergoing Coronary Artery Bypass Graft with Cardiopulmonary Bypass: A Randomized Controlled Trial" @default.
- W4240241827 doi "https://doi.org/10.21203/rs.3.rs-257557/v1" @default.
- W4240241827 hasPublicationYear "2021" @default.
- W4240241827 type Work @default.
- W4240241827 citedByCount "0" @default.
- W4240241827 crossrefType "posted-content" @default.
- W4240241827 hasAuthorship W4240241827A5015406742 @default.
- W4240241827 hasAuthorship W4240241827A5042088517 @default.
- W4240241827 hasAuthorship W4240241827A5073114768 @default.
- W4240241827 hasAuthorship W4240241827A5088426401 @default.
- W4240241827 hasBestOaLocation W42402418271 @default.
- W4240241827 hasConcept C126322002 @default.
- W4240241827 hasConcept C139940330 @default.
- W4240241827 hasConcept C164705383 @default.
- W4240241827 hasConcept C168563851 @default.
- W4240241827 hasConcept C178853913 @default.
- W4240241827 hasConcept C2775901492 @default.
- W4240241827 hasConcept C2776376669 @default.
- W4240241827 hasConcept C2776452961 @default.
- W4240241827 hasConcept C2776820930 @default.
- W4240241827 hasConcept C2777953023 @default.
- W4240241827 hasConcept C2778789114 @default.
- W4240241827 hasConcept C2778881276 @default.
- W4240241827 hasConcept C2780959883 @default.
- W4240241827 hasConcept C31861589 @default.
- W4240241827 hasConcept C35207712 @default.
- W4240241827 hasConcept C42219234 @default.
- W4240241827 hasConcept C58245268 @default.
- W4240241827 hasConcept C71924100 @default.
- W4240241827 hasConcept C80461066 @default.
- W4240241827 hasConcept C84393581 @default.
- W4240241827 hasConceptScore W4240241827C126322002 @default.
- W4240241827 hasConceptScore W4240241827C139940330 @default.
- W4240241827 hasConceptScore W4240241827C164705383 @default.
- W4240241827 hasConceptScore W4240241827C168563851 @default.
- W4240241827 hasConceptScore W4240241827C178853913 @default.
- W4240241827 hasConceptScore W4240241827C2775901492 @default.
- W4240241827 hasConceptScore W4240241827C2776376669 @default.
- W4240241827 hasConceptScore W4240241827C2776452961 @default.
- W4240241827 hasConceptScore W4240241827C2776820930 @default.
- W4240241827 hasConceptScore W4240241827C2777953023 @default.
- W4240241827 hasConceptScore W4240241827C2778789114 @default.
- W4240241827 hasConceptScore W4240241827C2778881276 @default.
- W4240241827 hasConceptScore W4240241827C2780959883 @default.
- W4240241827 hasConceptScore W4240241827C31861589 @default.
- W4240241827 hasConceptScore W4240241827C35207712 @default.
- W4240241827 hasConceptScore W4240241827C42219234 @default.
- W4240241827 hasConceptScore W4240241827C58245268 @default.
- W4240241827 hasConceptScore W4240241827C71924100 @default.
- W4240241827 hasConceptScore W4240241827C80461066 @default.
- W4240241827 hasConceptScore W4240241827C84393581 @default.
- W4240241827 hasLocation W42402418271 @default.
- W4240241827 hasLocation W42402418272 @default.
- W4240241827 hasOpenAccess W4240241827 @default.
- W4240241827 hasPrimaryLocation W42402418271 @default.
- W4240241827 hasRelatedWork W1942141672 @default.
- W4240241827 hasRelatedWork W2007477504 @default.
- W4240241827 hasRelatedWork W2010488693 @default.
- W4240241827 hasRelatedWork W2314165071 @default.
- W4240241827 hasRelatedWork W2347369757 @default.
- W4240241827 hasRelatedWork W2475327391 @default.
- W4240241827 hasRelatedWork W2582971951 @default.
- W4240241827 hasRelatedWork W3030532893 @default.
- W4240241827 hasRelatedWork W3097118066 @default.
- W4240241827 hasRelatedWork W2096901498 @default.
- W4240241827 isParatext "false" @default.
- W4240241827 isRetracted "false" @default.
- W4240241827 workType "article" @default.