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- W4240277683 abstract "In cell extracts of Xenopus eggs which oscillate between S and M phases of the cell cycle, the onset of mitosis is blocked by the presence of incompletely replicated DNA. In this report, we show that several artificial DNA templates (M13 single-stranded DNA and double-stranded plasmid DNA) can trigger this feedback pathway, which inhibits mitosis. Single-stranded M13 DNA is much more effective than double-stranded plasmid DNA at inhibiting the onset of mitosis. Furthermore, we have shown that low levels of M13 single-stranded DNA and high levels of double-stranded plasmid DNA can elevate the tyrosine kinase activity responsible for phosphorylating p34cdc2, thereby inactivating maturation-promoting factor and inhibiting entry into mitosis. This constitutes a simplified system with which to study the signal transduction pathway from the DNA template to the tyrosine kinase responsible for inhibiting p34cdc2 activity." @default.
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- W4240277683 date "1992-07-01" @default.
- W4240277683 modified "2023-10-16" @default.
- W4240277683 title "In Vitro Cell Cycle Arrest Induced by Using Artificial DNA Templates" @default.
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- W4240277683 doi "https://doi.org/10.1128/mcb.12.7.3216-3223.1992" @default.
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