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- W4240295512 abstract "Carbamazepine (CBZ), a widely used anticonvulsant, occasionally causes serious hematologic disorders. A 12-year-old boy was admitted because of a diffuse petechial rash and profound thrombocytopenia (10 × 109 platelets/l), after having been treated for epilepsy with CBZ for 12 days. Seven days following withdrawal of CBZ and initiation of prednisolone therapy, the platelet count recovered. In a subsequent challenge test with CBZ, platelet counts again decreased, and the levels of platelet-associated IgG and serum interleukin-6 increased. No antibodies against platelet glycoprotein IIb/IIIa or Ib were detected in plasma. We believe that this is the first reported occasion when CBZ-induced thrombocytopenia has been defined by a rechallenge test. Am. J. Hematol. 64:52–55, 1999. © 1999 Wiley-Liss, Inc." @default.
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- W4240295512 date "1999-09-01" @default.
- W4240295512 modified "2023-10-14" @default.
- W4240295512 title "Carbamazepine‐induced thrombocytopenia defined by a challenge test" @default.
- W4240295512 doi "https://doi.org/10.1002/(sici)1096-8652(199909)62:1<52::aid-ajh9>3.3.co;2-5" @default.
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