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- W4240320260 abstract "Exchange between the nucleus and the cytoplasm is controlled by nuclear pore complexes (NPCs). In animals, NPCs are anchored by the nuclear lamina, which ensures their even distribution and proper organization of chromosomes. Fungi do not possess a lamina and how they arrange their chromosomes and NPCs is unknown. Here, we show that motor-driven motility of NPCs organizes the fungal nucleus. In Ustilago maydis, Aspergillus nidulans, and Saccharomyces cerevisiae fluorescently labeled NPCs showed ATP-dependent movements at ~1.0 µm/s. In S. cerevisiae and U. maydis, NPC motility prevented NPCs from clustering. In budding yeast, NPC motility required F-actin, whereas in U. maydis, microtubules, kinesin-1, and dynein drove pore movements. In the latter, pore clustering resulted in chromatin organization defects and led to a significant reduction in both import and export of GFP reporter proteins. This suggests that fungi constantly rearrange their NPCs and corresponding chromosomes to ensure efficient nuclear transport and thereby overcome the need for a structural lamina. PMID: 22851316" @default.
- W4240320260 created "2022-05-12" @default.
- W4240320260 creator A5026135455 @default.
- W4240320260 creator A5090636312 @default.
- W4240320260 date "2012-08-24" @default.
- W4240320260 modified "2023-09-28" @default.
- W4240320260 title "Faculty Opinions recommendation of Motor-driven motility of fungal nuclear pores organizes chromosomes and fosters nucleocytoplasmic transport." @default.
- W4240320260 doi "https://doi.org/10.3410/f.717952971.793459370" @default.
- W4240320260 hasPublicationYear "2012" @default.
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