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• W4240330299 abstract "Purpose/ObjectiveThe aims of this retrospective study were 1) to evaluate the impact of local tumor extension in early stage NHL of the nasal cavity and 2) to compare the treatment outcome of radiation (RT) alone with that of combined chemoradiation (CRT).Materials/MethodsBetween Mar. 1993-June 1999, 90 consecutive patients with stage IE and IIE (Ann Arbor) primary NHL of the nasal cavity were treated in Shanghai Cancer Hospital. 74 (82%) patients had stage IE and 16 (18%) had stage IIE disease. 31 patients had primary disease limited to the nasal cavity (Group I); 35 patients had disease invading one adjacent structure beyond the nasal cavity (Group II); and 24 patients had disease invading two or more adjacent structures beyond the nasal cavity (Group III).80 patients received CRT and 10 patients received RT only. The median dose to the primary disease was 54Gy (45.2–71.5Gy). 35 patients with stage IE disease received involved field RT. All other patients received RT to their primary and whole neck. CHOP ± Me-CCNU based chemotherapy was used.ResultsThe median follow-up for all 90 patients was 54 months. The median survival was 58.7 months (13–81 months). The actuarial 5-year overall survival, disease-free survival, and local control rates were 46%, 42.5%, and 92%, respectively. When comparing the outcome of the 3 groups of patients, we found that the extent of local disease predicted overall survival (68.3%, 43.2%, and 27.7%, p = 0.001), local control (100%, 90.8%, and 77.5%, p = 0.002), and distant relapse (11.6%, 30.4%, and 51.1%, p = 0.0001). Ann Arbor stage did not predict for any endpoint studied. Multivariate analysis also showed that combined CRT significantly improved 5-year overall survival (48.1% vs. 40.2% for patients receiving RT alone, p = 0.05) and reduced distant relapse (27.2% vs. 51.1%, p = 0.014). CRT had no effect on local control (p = 0.122).ConclusionsExtent of local disease is a strong prognostic factor in patients with early stage primary nasal NHL treated with CRT or RT alone. Ann Arbor stage was not a prognostic factor in our patient group. The addition of chemotherapy to RT significantly improves survival and decreases distant relapse.View Large Image Figure ViewerDownload (PPT) Purpose/ObjectiveThe aims of this retrospective study were 1) to evaluate the impact of local tumor extension in early stage NHL of the nasal cavity and 2) to compare the treatment outcome of radiation (RT) alone with that of combined chemoradiation (CRT). The aims of this retrospective study were 1) to evaluate the impact of local tumor extension in early stage NHL of the nasal cavity and 2) to compare the treatment outcome of radiation (RT) alone with that of combined chemoradiation (CRT). Materials/MethodsBetween Mar. 1993-June 1999, 90 consecutive patients with stage IE and IIE (Ann Arbor) primary NHL of the nasal cavity were treated in Shanghai Cancer Hospital. 74 (82%) patients had stage IE and 16 (18%) had stage IIE disease. 31 patients had primary disease limited to the nasal cavity (Group I); 35 patients had disease invading one adjacent structure beyond the nasal cavity (Group II); and 24 patients had disease invading two or more adjacent structures beyond the nasal cavity (Group III).80 patients received CRT and 10 patients received RT only. The median dose to the primary disease was 54Gy (45.2–71.5Gy). 35 patients with stage IE disease received involved field RT. All other patients received RT to their primary and whole neck. CHOP ± Me-CCNU based chemotherapy was used. Between Mar. 1993-June 1999, 90 consecutive patients with stage IE and IIE (Ann Arbor) primary NHL of the nasal cavity were treated in Shanghai Cancer Hospital. 74 (82%) patients had stage IE and 16 (18%) had stage IIE disease. 31 patients had primary disease limited to the nasal cavity (Group I); 35 patients had disease invading one adjacent structure beyond the nasal cavity (Group II); and 24 patients had disease invading two or more adjacent structures beyond the nasal cavity (Group III). 80 patients received CRT and 10 patients received RT only. The median dose to the primary disease was 54Gy (45.2–71.5Gy). 35 patients with stage IE disease received involved field RT. All other patients received RT to their primary and whole neck. CHOP ± Me-CCNU based chemotherapy was used. ResultsThe median follow-up for all 90 patients was 54 months. The median survival was 58.7 months (13–81 months). The actuarial 5-year overall survival, disease-free survival, and local control rates were 46%, 42.5%, and 92%, respectively. When comparing the outcome of the 3 groups of patients, we found that the extent of local disease predicted overall survival (68.3%, 43.2%, and 27.7%, p = 0.001), local control (100%, 90.8%, and 77.5%, p = 0.002), and distant relapse (11.6%, 30.4%, and 51.1%, p = 0.0001). Ann Arbor stage did not predict for any endpoint studied. Multivariate analysis also showed that combined CRT significantly improved 5-year overall survival (48.1% vs. 40.2% for patients receiving RT alone, p = 0.05) and reduced distant relapse (27.2% vs. 51.1%, p = 0.014). CRT had no effect on local control (p = 0.122). The median follow-up for all 90 patients was 54 months. The median survival was 58.7 months (13–81 months). The actuarial 5-year overall survival, disease-free survival, and local control rates were 46%, 42.5%, and 92%, respectively. When comparing the outcome of the 3 groups of patients, we found that the extent of local disease predicted overall survival (68.3%, 43.2%, and 27.7%, p = 0.001), local control (100%, 90.8%, and 77.5%, p = 0.002), and distant relapse (11.6%, 30.4%, and 51.1%, p = 0.0001). Ann Arbor stage did not predict for any endpoint studied. Multivariate analysis also showed that combined CRT significantly improved 5-year overall survival (48.1% vs. 40.2% for patients receiving RT alone, p = 0.05) and reduced distant relapse (27.2% vs. 51.1%, p = 0.014). CRT had no effect on local control (p = 0.122). ConclusionsExtent of local disease is a strong prognostic factor in patients with early stage primary nasal NHL treated with CRT or RT alone. Ann Arbor stage was not a prognostic factor in our patient group. The addition of chemotherapy to RT significantly improves survival and decreases distant relapse. Extent of local disease is a strong prognostic factor in patients with early stage primary nasal NHL treated with CRT or RT alone. Ann Arbor stage was not a prognostic factor in our patient group. The addition of chemotherapy to RT significantly improves survival and decreases distant relapse." @default.
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• W4240330299 date "2004-09-01" @default.
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• W4240330299 title "Primary non-Hodgkin’s lymphoma (NHL) of the nasal cavity: The evaluation of prognostic significance of local tumor extension and combined modality treatment" @default.
• W4240330299 doi "https://doi.org/10.1016/s0360-3016(04)01814-0" @default.
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