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- W4240414329 abstract "Abstract Background Patients' own perceptions and evaluations of symptoms, functioning and other health-related factors, i.e. Patient Reported Outcomes (PROs), are important elements for providing good patient care. Symptoms are subjective and best elicited by the patient orally or by using PRO measures (PROMs). Reference values on frequently used PROMs facilitate the interpretation of PROMs scores both in clinics and research settings, by comparing patient data with relevant samples from the general population.Objectives Study objectives were to (1) present reference values for the M.D. Anderson Symptom inventory (MDASI) (2) examine the occurrence and intensity of symptoms assessed by the MDASI in a general Norwegian population sample, and (3) examine factors associated with higher symptom burden defined as the sum score of all symptoms, and factors associated with symptoms' interference on functionsMethods In 2015, MDASI was sent by mail to a representative sample of the general Norwegian population (N = 6165). Medical comorbidities were assessed by the Self-Administered Comorbidity Questionnaire. Depression was self-reported on the Patient Health Questionnaire 9 (PHQ-9). Linear multivariable regression analysis was used to examine for factors associated with MDASI sum score and factors associated with symptoms’ interference on functions.Results The response rate was 36%. More females (54%) than males (46%) responded. Mean age was 55 years (SD 14). The most frequent symptoms were fatigue (59.7%), drowsiness (56.2%) and pain (56.1%). Fatigue, pain and disturbed sleep had the highest mean scores. The presence of one or more comorbidities, increasing PHQ-9 score and lower level of education were associated with higher MDASI sum score (p<0.001). The MDASI sum score and the PHQ-9 score were positively associated with all interference items (p<0.001) except for walking (p=0.22).Conclusion This study provides the first Norwegian reference values for the MDASI. The presence of one or more comorbidities, higher level of depressive symptoms and lower level of education were significantly associated with higher MDASI sum score. These covariates must be controlled for when using the reference values." @default.
- W4240414329 created "2022-05-12" @default.
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- W4240414329 date "2020-01-06" @default.
- W4240414329 modified "2023-10-17" @default.
- W4240414329 title "Symptoms in the general Norwegian population - prevalence and associated factors" @default.
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- W4240414329 doi "https://doi.org/10.21203/rs.2.20079/v1" @default.
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