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- W4240426323 abstract "Peliglitazar is a dual α/γ peroxisome proliferator‐activated receptor activator used for the treatment of type II diabetes. The metabolism and disposition of [ 14 C]‐labeled peliglitazar were investigated in 10 healthy male subjects with and without bile collection after a single 10‐mgoral dose. Major phase I metabolites were O ‐demethylpeliglitazar, 5‐methyl‐2‐phenyoxzayl‐4‐acetic acid and O ‐dealkylpeliglitazar yielded by O‐dealkylation cleavage of peliglitazar, yielded by methyl hydroxylation, 17‐hydroxy peliglitazar yielded by aryl hydroxylation, and 9‐hydroxy peliglitazar yielded by aliphatic hydroxylation. Combination of these metabolic reactions yielded 12‐hydroxy O ‐demethylpeliglitazar and 9‐hydroxy O ‐demethylpeliglitazar. Furthermore, an oxazole ring‐opened metabolite was also detected. Glucuronide conjugates of the hydroxyl or carboxylic acid moieties of peliglitazar and its metabolites were significant in plasma, bile, and excreta. Peliglitazar and its acyl glucuronides were the major components in plasma. The major portion of the radioactive dose was recovered in feces." @default.
- W4240426323 created "2022-05-12" @default.
- W4240426323 creator A5003912539 @default.
- W4240426323 date "2013-10-13" @default.
- W4240426323 modified "2023-09-26" @default.
- W4240426323 title "Peliglitazar" @default.
- W4240426323 cites W2156214908 @default.
- W4240426323 doi "https://doi.org/10.1002/9781118541203.xen476" @default.
- W4240426323 hasPublicationYear "2013" @default.
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