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- W4240508719 abstract "Leptin, yakın zamanda keşfedilen ve halen araştırılmakta olan, metabolizmayı ve tüm vücut sistemlerini düzenleyici bir hormondur. Leptin kelimesi Yunanca ince, zayıf anlamına gelen leptos kelimesinden türetilmiştir. Leptin hormonu, Zhang ve ekibi tarafından 1994 yılında keşfedildikten sonra üzerinde geniş incelemeler yapılmış ve obezite geninin 167 amino asitli hormonal protein ürünü olduğu bulunmuştur. Hormon aşırı gıda alan ve az enerji tüketen obez farelerde genetik defekt olarak tanımlanmış, gene “ob” ve mutasyonlu obez farelere “ob/ob” denmiştir. İnsanlarda 7. kromozomun uzun kolunda bulunan (7q31) ob/ob geninde kodlanmıştır. Başlangıcta doygunluk ve enerji dengesi ile ilgili olduğu tanımlanan leptinin adipositlerden hipotalamusa feedback etkili antiobezite faktörü olduğu ileri sürülmüştür. Anahtar Kelimeler: Leptin, hayvanlar, insan" @default.
- W4240508719 created "2022-05-12" @default.
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- W4240508719 date "2016-06-23" @default.
- W4240508719 modified "2023-10-16" @default.
- W4240508719 title "LEPTİN HORMONU" @default.
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- W4240508719 doi "https://doi.org/10.24880/maeuvfd.260792" @default.
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