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- W4240511568 abstract "Multi-drug-resistant Enterobacteriales are an increasing problem and include those mediated by extended-spectrum β-lactamases (ESBLs) and carpapenemase production (CPE). Third-generation cephalosporins are inactivated by ESBLs but for CPEs there are much fewer options for treatment. The challenge in detection, management, and treatment is compounded by CPEs occurring amongst such a broad category of Gram-negative bacilli and because the genetic elements are very mobile, often being quickly and widely disseminated through plasmids. Phenotypic tests for identification have their limitations and there is increasing emphasis on PCR with microarrays and whole genome sequencing being available in specialist centres. Colistin is often the drug of first choice for CPE infections but is usually combined with another agent such as an aminoglycoside. Aggressive infection prevention and control precautions are mandatory given the propensity to spread, the reduced options for treatment, and a lack of insight to patterns and duration of carriage." @default.
- W4240511568 created "2022-05-12" @default.
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- W4240511568 date "2020-02-01" @default.
- W4240511568 modified "2023-09-24" @default.
- W4240511568 title "Case 34" @default.
- W4240511568 doi "https://doi.org/10.1093/med/9780198846482.003.0034" @default.
- W4240511568 hasPublicationYear "2020" @default.
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