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- W4240544174 abstract "Parkinson's disease is a neurodegenerative disease that is consequent to the loss of brain dopamine (DA) cells. These abnormalities are thought, in part, to be a manifestation of increased free radical production during the metabolism of catecholamines. The antiapoptic agent, bcl-2, has been shown to protect cells against the toxic effects of reactive oxygen species (ROS). Thus, we tested whether bcl-2 could attenuate the toxic effects of DA on immortalized neural cells. Our results show that DA caused dose-dependent cell death. The use of confocal microscopy and flow cytometry demonstrated that DA caused cell death through an apoptotic process. Moreover, DA caused a marked increase in ROS in these cells. Furthermore, overexpression of bcl-2 caused significant protection against DA-induced apoptosis. These results are discussed in terms of their support for a role of bcl-2 in the development of Parkinson's disease. Synapse 35:228–233, 2000. © 2000 Wiley-Liss, Inc." @default.
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- W4240544174 date "2000-03-01" @default.
- W4240544174 modified "2023-09-27" @default.
- W4240544174 title "Bcl-2 overexpression attenuates dopamine-induced apoptosis in an immortalized neural cell line by suppressing the production of reactive oxygen species" @default.
- W4240544174 doi "https://doi.org/10.1002/(sici)1098-2396(20000301)35:3<228::aid-syn8>3.3.co;2-r" @default.
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