Matches in SemOpenAlex for { <https://semopenalex.org/work/W4240599779> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4240599779 endingPage "27" @default.
- W4240599779 startingPage "27" @default.
- W4240599779 abstract "In the early 1980s, studies in type 1 diabetes suggested that glomerular filtration rate (GFR) loss begins with the onset of macroalbuminuria. However, recent evidence indicates that up to one-quarter of subjects with diabetes reach a GFR of less than 60 ml/min/1.73 m 2 (chronic kidney disease [CKD] stage 3) before developing micro- or macroalbuminuria. Furthermore, the prospective loss of GFR can be detected in early diabetic nephropathy (DN) well before CKD stage 3. Early GFR loss usually reflects DN in type 1 diabetes but, in older patients with type 2 diabetes, the assessment of early GFR loss needs to take into account the effects of ageing. The assessment of GFR is now feasible at clinical level, using formulas based on serum creatinine, age, gender and ethnicity. Overall, the estimation of early GFR loss is more accurate with the Chronic Kidney Disease Epidemiology (CKD–EPI) formula than with the Modification of Diet in Renal Disease (MDRD) study formula, but there is some evidence that the CKD-EPI formula does not exhibit better performance than the MDRD formula for estimating GFR in diabetes. Both formulas underestimate GFR in the hyperfiltration range. Formulas based on the reciprocal of cystatin C can also be used to estimate GFR, but their cost and lack of assay standardisation have delayed their use at clinical level. In summary, early GFR loss is an important marker of DN as well as a potentially reversible target for interventions in DN." @default.
- W4240599779 created "2022-05-12" @default.
- W4240599779 creator A5006069892 @default.
- W4240599779 creator A5018714035 @default.
- W4240599779 creator A5036715888 @default.
- W4240599779 creator A5043247231 @default.
- W4240599779 date "2010-01-01" @default.
- W4240599779 modified "2023-10-17" @default.
- W4240599779 title "Early Glomerular Filtration Rate Loss as a Marker of Diabetic Nephropathy" @default.
- W4240599779 doi "https://doi.org/10.17925/ee.2012.08.01.27" @default.
- W4240599779 hasPublicationYear "2010" @default.
- W4240599779 type Work @default.
- W4240599779 citedByCount "3" @default.
- W4240599779 countsByYear W42405997792015 @default.
- W4240599779 countsByYear W42405997792017 @default.
- W4240599779 countsByYear W42405997792021 @default.
- W4240599779 crossrefType "journal-article" @default.
- W4240599779 hasAuthorship W4240599779A5006069892 @default.
- W4240599779 hasAuthorship W4240599779A5018714035 @default.
- W4240599779 hasAuthorship W4240599779A5036715888 @default.
- W4240599779 hasAuthorship W4240599779A5043247231 @default.
- W4240599779 hasBestOaLocation W42405997791 @default.
- W4240599779 hasConcept C126322002 @default.
- W4240599779 hasConcept C126894567 @default.
- W4240599779 hasConcept C134018914 @default.
- W4240599779 hasConcept C159641895 @default.
- W4240599779 hasConcept C2777180221 @default.
- W4240599779 hasConcept C2778653478 @default.
- W4240599779 hasConcept C2779548226 @default.
- W4240599779 hasConcept C2779922275 @default.
- W4240599779 hasConcept C2780306776 @default.
- W4240599779 hasConcept C2781184683 @default.
- W4240599779 hasConcept C555293320 @default.
- W4240599779 hasConcept C71924100 @default.
- W4240599779 hasConceptScore W4240599779C126322002 @default.
- W4240599779 hasConceptScore W4240599779C126894567 @default.
- W4240599779 hasConceptScore W4240599779C134018914 @default.
- W4240599779 hasConceptScore W4240599779C159641895 @default.
- W4240599779 hasConceptScore W4240599779C2777180221 @default.
- W4240599779 hasConceptScore W4240599779C2778653478 @default.
- W4240599779 hasConceptScore W4240599779C2779548226 @default.
- W4240599779 hasConceptScore W4240599779C2779922275 @default.
- W4240599779 hasConceptScore W4240599779C2780306776 @default.
- W4240599779 hasConceptScore W4240599779C2781184683 @default.
- W4240599779 hasConceptScore W4240599779C555293320 @default.
- W4240599779 hasConceptScore W4240599779C71924100 @default.
- W4240599779 hasIssue "1" @default.
- W4240599779 hasLocation W42405997791 @default.
- W4240599779 hasOpenAccess W4240599779 @default.
- W4240599779 hasPrimaryLocation W42405997791 @default.
- W4240599779 hasRelatedWork W10381212 @default.
- W4240599779 hasRelatedWork W14579190 @default.
- W4240599779 hasRelatedWork W14643057 @default.
- W4240599779 hasRelatedWork W18342598 @default.
- W4240599779 hasRelatedWork W19878240 @default.
- W4240599779 hasRelatedWork W220526 @default.
- W4240599779 hasRelatedWork W24065084 @default.
- W4240599779 hasRelatedWork W3506599 @default.
- W4240599779 hasRelatedWork W8706952 @default.
- W4240599779 hasRelatedWork W1788071 @default.
- W4240599779 hasVolume "8" @default.
- W4240599779 isParatext "false" @default.
- W4240599779 isRetracted "false" @default.
- W4240599779 workType "article" @default.