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- W4240600712 abstract "Two-fold or greater increases of Factor VIII procoagulant activity (VIII AHF) have been described following the administration of adrenalin in normal individuals and in some patients with VWD.VIII AHF and Factor VIII-like antigen (VIII AGN) levels were measured pre and one hour post the s. q. injection of adrenalin 0.35 cc. in 4 adult VWD patients and in 10 adult hemophiliacs with VIII AHF levels ranging from 1-29%, normal VIII AGN levels and normal VIII VWF levels as measured by the washed platelet ristocetin assay. Eighteen normal adults served as controls. The four patients with VWD showed two-fold or greater increases of VIII AHF with variable VIII AGN responses. All 10 hemophiliacs showed no change in VIII AHF with significant increases in VIII AGN when analyzed by the paired t-test. The fixed rate of VIII AHF production, release or activation observed in hemophiliacs may help to explain the constancy of VIII AHF levels in individual hemophiliacs and their affected family members. Furthermore, this simple provocative test may be helpful in distinguishing certain VWD patients from those with hemophilia." @default.
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- W4240600712 date "1977-01-01" @default.
- W4240600712 modified "2023-09-28" @default.
- W4240600712 title "Comparison of Factor VIII Levels After Adrenalin IN Hemophilia a and von Willebrand’s Disease (VWD)" @default.
- W4240600712 doi "https://doi.org/10.1055/s-0039-1682513" @default.
- W4240600712 hasPublicationYear "1977" @default.
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