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- W4240609871 abstract "Abstract Epilepsy and migraine have been associated since William Richard Gowers’ time. Both are common, paroxysmal, chronic neurologic disorders that share many clinical and epidemiologic features. Both conditions may present with visual, cognitive and sensorimotor features, arise from the cerebral cortex, and are modulated by subcortical connections. They are linked to genetic factors, and often have good prognoses. At times, the clinical distinction between migraine and epilepsy can be difficult and the differential diagnosis problematic. The electroencephalogram (EEG) is very helpful in the differentiation of migralepsy (seizures triggered by a migraine aura), confusional migraine, and certain epilepsy syndromes associated with migraine-like headaches such as benign occipital epilepsy. Migraine and epilepsy occur together in a number of infrequent genetic disorders (eg. MELAS, MERRF and CADASIL). The pathophysiology of migraine is not completely understood but significant advances have recently been made. The treatment options for abortive interventions for the two conditions are different, but the options for preventive treatments are surprisingly similar. This chapter discusses Gowers’ contribution to migraine and epilepsy, the epidemiology of the two conditions, diagnostic challenges, and our current understanding of genetics, pathophysiology and treatment." @default.
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- W4240609871 date "2012-10-01" @default.
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- W4240609871 title "Migraine" @default.
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- W4240609871 doi "https://doi.org/10.1093/med/9780199796793.003.0007" @default.
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