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- W4240633480 abstract "The paper in the current issue by Parkins and Fowler (1985) describes an elegant study of the effects of paraquat poisoning on lung function in mice. They have shown that respiration rate provides a sensitive index of paraquat injury and that dose-response curves can be obtained. They found that irradiation given as a single dose 3 days after the toxin did not reverse paraquat lung injury, but rather that it exacerbated the damage. This is a disappointing result, but the interaction is not unexpected as paraquat is a highly electron-affinic radiosensitiser, and as both modalities inflict injury by the generation of free radicals. Due allowance was made for this possibility when we used whole-lung irradiation clinically (Webb et al, 1984)." @default.
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- W4240633480 date "1985-11-01" @default.
- W4240633480 modified "2023-09-24" @default.
- W4240633480 title "Lung irradiation for paraquat toxicity" @default.
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- W4240633480 doi "https://doi.org/10.1259/0007-1285-58-695-1144-a" @default.
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