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• W4240636299 abstract "This chapter discusses the stereochemistry and preparation of hydroxycitrate. In nonruminant mammals the acetyl-CoA used for lipogenesis is generated largely from citrate in a reaction catalyzed by ATP: citrate lyase. Hydroxycitrate is a competitive inhibitor of the reaction with respect to citrate. The de novo syntheses of long-chain fatty acids and 3-β-hydroxysterols are inhibited to about the same extent by hydroxycitrate. Both pathways are extramitochondrial and both use acetyl-CoA as a carbon source. In nonruminant mammals extramitochondrial acetyl-CoA is made predominantly via the citrate cleavage reaction. Hydroxycitrate can therefore be expected to inhibit both pathways. The degrees to which both pathways are inhibited will depend on the relative affinity of their acetyl-CoA-utilizing enzymes for acetyl-CoA. Metabolite analyses of perfused livers show that addition of either hydroxycitrate or oleate causes a crossover at the phosphofructokinase reaction. This indicates a slowing down of glycolysis, which is regulated through phosphofructokinase. It is found that ketone production by perfused livers from fed rats, which occurs at a considerably slower rate, is inhibited by hydroxycitrate." @default.
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• W4240636299 date "1981-01-01" @default.
• W4240636299 modified "2023-09-25" @default.
• W4240636299 title "[36] Hydroxycitrate" @default.
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• W4240636299 doi "https://doi.org/10.1016/s0076-6879(81)72038-x" @default.
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