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• W4240693535 endingPage "2073" @default.
• W4240693535 startingPage "2069" @default.
• W4240693535 abstract "Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin-6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with human herpesvirus 8 (HHV8) infection. In a prospective study of 23 HIV-infected patients with MCD, clinical symptoms of MCD were present at 45 visits, whereas patients were in chemotherapy-induced clinical remission at 50 visits. Symptoms were associated with a high level of serum C reactive protein, high HHV8 viral load in peripheral blood mononuclear cells, and high plasma human IL-6 and IL-10 levels. Strong correlations between plasma IL-6 and plasma IL-10 with the HHV8 viral load suggest that both cytokines may be involved in the pathogenesis of this virus-associated lymphoproliferative disorder." @default.
• W4240693535 created "2022-05-12" @default.
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• W4240693535 date "2000-09-15" @default.
• W4240693535 modified "2023-10-18" @default.
• W4240693535 title "High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric Castleman disease in HIV-infected patients" @default.
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• W4240693535 doi "https://doi.org/10.1182/blood.v96.6.2069.h8002069_2069_2073" @default.
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