Matches in SemOpenAlex for { <https://semopenalex.org/work/W4240702982> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4240702982 endingPage "399" @default.
- W4240702982 startingPage "399" @default.
- W4240702982 abstract "Acute injury to the spinal cord initiates a sequence of vascular, biochemical, and inflammatory events that result in the development of secondary tissue damage. Experimental studies and clinical trials in humans have demonstrated that the extent of this secondary tissue damage can be limited by pharmacologic intervention at appropriate intervals after injury. High doses of methylprednisolone sodium succinate (MPSS) improve the outcome of acute spinal cord injury in humans if treatment is initiated within 8 hours of injury. Starting therapy more than 8 hours after injury is detrimental to outcome. The clinical efficacy of methylprednisolone in improving the outcome of canine spinal cord injuries has not yet been demonstrated and its use by veterinarians is controversial. Many dogs are not seen by a veterinarian within the 8-hour window after injury, and these dogs frequently are treated with nonsteroidal anti-inflammatory drugs or large doses of dexamethasone or prednisone before methylprednisolone treatment can be initiated, thus increasing the risk of severe adverse effects. Other drugs that may provide safer and more effective alternatives to methylprednisolone include thyrotropin-releasing hormone (TRH), the 21-aminosteroids, and kappa opioid agonists. Recent studies suggest that modulation of the influx of inflammatory cells and activation of endogenous microglial cells may provide another means of improving the outcome of acute spinal cord injuries. Many drugs being developed to treat acute spinal cord injury have shown promising results when evaluated experimentally. However, any proposed therapeutic strategy should be evaluated in prospective blinded clinical trials before being adopted in clinics." @default.
- W4240702982 created "2022-05-12" @default.
- W4240702982 creator A5038624877 @default.
- W4240702982 date "1999-01-01" @default.
- W4240702982 modified "2023-09-27" @default.
- W4240702982 title "Current Concepts in the Management of Acute Spinal Cord Injury" @default.
- W4240702982 doi "https://doi.org/10.1892/0891-6640(1999)013<0399:ccitmo>2.3.co;2" @default.
- W4240702982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10499720" @default.
- W4240702982 hasPublicationYear "1999" @default.
- W4240702982 type Work @default.
- W4240702982 citedByCount "13" @default.
- W4240702982 countsByYear W42407029822017 @default.
- W4240702982 countsByYear W42407029822018 @default.
- W4240702982 countsByYear W42407029822020 @default.
- W4240702982 crossrefType "journal-article" @default.
- W4240702982 hasAuthorship W4240702982A5038624877 @default.
- W4240702982 hasBestOaLocation W42407029821 @default.
- W4240702982 hasConcept C118552586 @default.
- W4240702982 hasConcept C126322002 @default.
- W4240702982 hasConcept C197934379 @default.
- W4240702982 hasConcept C2778334475 @default.
- W4240702982 hasConcept C2780372218 @default.
- W4240702982 hasConcept C2780775167 @default.
- W4240702982 hasConcept C42219234 @default.
- W4240702982 hasConcept C535046627 @default.
- W4240702982 hasConcept C71924100 @default.
- W4240702982 hasConcept C98274493 @default.
- W4240702982 hasConceptScore W4240702982C118552586 @default.
- W4240702982 hasConceptScore W4240702982C126322002 @default.
- W4240702982 hasConceptScore W4240702982C197934379 @default.
- W4240702982 hasConceptScore W4240702982C2778334475 @default.
- W4240702982 hasConceptScore W4240702982C2780372218 @default.
- W4240702982 hasConceptScore W4240702982C2780775167 @default.
- W4240702982 hasConceptScore W4240702982C42219234 @default.
- W4240702982 hasConceptScore W4240702982C535046627 @default.
- W4240702982 hasConceptScore W4240702982C71924100 @default.
- W4240702982 hasConceptScore W4240702982C98274493 @default.
- W4240702982 hasIssue "5" @default.
- W4240702982 hasLocation W42407029821 @default.
- W4240702982 hasLocation W42407029822 @default.
- W4240702982 hasOpenAccess W4240702982 @default.
- W4240702982 hasPrimaryLocation W42407029821 @default.
- W4240702982 hasRelatedWork W1775685450 @default.
- W4240702982 hasRelatedWork W1997360763 @default.
- W4240702982 hasRelatedWork W2024521825 @default.
- W4240702982 hasRelatedWork W2354519543 @default.
- W4240702982 hasRelatedWork W2368070621 @default.
- W4240702982 hasRelatedWork W2369401174 @default.
- W4240702982 hasRelatedWork W2380634197 @default.
- W4240702982 hasRelatedWork W2390195514 @default.
- W4240702982 hasRelatedWork W40053288 @default.
- W4240702982 hasRelatedWork W4230916704 @default.
- W4240702982 hasVolume "13" @default.
- W4240702982 isParatext "false" @default.
- W4240702982 isRetracted "false" @default.
- W4240702982 workType "article" @default.