Matches in SemOpenAlex for { <https://semopenalex.org/work/W4240717991> ?p ?o ?g. }
- W4240717991 endingPage "842" @default.
- W4240717991 startingPage "835" @default.
- W4240717991 abstract "The purpose of these studies was to examine the role of cytokines in the pathogenesis of cisplatin nephrotoxicity. Injection of mice with cisplatin (20 mg/kg) led to severe renal failure. The expression of cytokines, chemokines, and ICAM-1 in kidney was measured by ribonuclease protection assays and RT-PCR. We found significant upregulation of TNF-α, TGF-β, RANTES, MIP-2, MCP-1, TCA3, IL-1β, and ICAM-1 in kidneys from cisplatin-treated animals. In addition, serum, kidney, and urine levels of TNF-α measured by ELISA were increased by cisplatin. Inhibitors of TNF-α production (GM6001, pentoxifylline) and TNF-α Ab’s reduced serum and kidney TNF-α protein levels and also blunted the cisplatin-induced increases in TNF-α, TGF-β, RANTES, MIP-2, MCP-1, and IL-1β, but not ICAM-1, mRNA. In addition, the TNF-α inhibitors also ameliorated cisplatin-induced renal dysfunction and reduced cisplatin-induced structural damage. Likewise, TNF-α–deficient mice were resistant to cisplatin nephrotoxicity. These results indicate cisplatin nephrotoxicity is characterized by activation of proinflammatory cytokines and chemokines. TNF-α appears to play a central role in the activation of this cytokine response and also in the pathogenesis of cisplatin renal injury." @default.
- W4240717991 created "2022-05-12" @default.
- W4240717991 creator A5051664257 @default.
- W4240717991 creator A5061050826 @default.
- W4240717991 date "2002-09-15" @default.
- W4240717991 modified "2023-10-18" @default.
- W4240717991 title "TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity" @default.
- W4240717991 cites W1545966740 @default.
- W4240717991 cites W1749117680 @default.
- W4240717991 cites W1865602869 @default.
- W4240717991 cites W1964390988 @default.
- W4240717991 cites W1966110021 @default.
- W4240717991 cites W1967908792 @default.
- W4240717991 cites W1969751051 @default.
- W4240717991 cites W1974863073 @default.
- W4240717991 cites W1976552887 @default.
- W4240717991 cites W1977721476 @default.
- W4240717991 cites W2007058758 @default.
- W4240717991 cites W2012726316 @default.
- W4240717991 cites W2014886449 @default.
- W4240717991 cites W2015746497 @default.
- W4240717991 cites W2019007505 @default.
- W4240717991 cites W2019316722 @default.
- W4240717991 cites W2019617863 @default.
- W4240717991 cites W2035601393 @default.
- W4240717991 cites W2037283275 @default.
- W4240717991 cites W2044312475 @default.
- W4240717991 cites W2046658387 @default.
- W4240717991 cites W2051150238 @default.
- W4240717991 cites W2051354793 @default.
- W4240717991 cites W2064255019 @default.
- W4240717991 cites W2065578442 @default.
- W4240717991 cites W2073769825 @default.
- W4240717991 cites W2073809001 @default.
- W4240717991 cites W2079029234 @default.
- W4240717991 cites W2085170367 @default.
- W4240717991 cites W2086417798 @default.
- W4240717991 cites W2086910295 @default.
- W4240717991 cites W2092557822 @default.
- W4240717991 cites W2119983127 @default.
- W4240717991 cites W2144152742 @default.
- W4240717991 cites W2159865570 @default.
- W4240717991 cites W2164391817 @default.
- W4240717991 cites W2164492572 @default.
- W4240717991 cites W2170106455 @default.
- W4240717991 cites W2331176038 @default.
- W4240717991 cites W23360501 @default.
- W4240717991 cites W2401887519 @default.
- W4240717991 cites W4238252095 @default.
- W4240717991 doi "https://doi.org/10.1172/jci200215606" @default.
- W4240717991 hasPublicationYear "2002" @default.
- W4240717991 type Work @default.
- W4240717991 citedByCount "631" @default.
- W4240717991 countsByYear W42407179912012 @default.
- W4240717991 countsByYear W42407179912013 @default.
- W4240717991 countsByYear W42407179912014 @default.
- W4240717991 countsByYear W42407179912015 @default.
- W4240717991 countsByYear W42407179912016 @default.
- W4240717991 countsByYear W42407179912017 @default.
- W4240717991 countsByYear W42407179912018 @default.
- W4240717991 countsByYear W42407179912019 @default.
- W4240717991 countsByYear W42407179912020 @default.
- W4240717991 countsByYear W42407179912021 @default.
- W4240717991 countsByYear W42407179912022 @default.
- W4240717991 countsByYear W42407179912023 @default.
- W4240717991 crossrefType "journal-article" @default.
- W4240717991 hasAuthorship W4240717991A5051664257 @default.
- W4240717991 hasAuthorship W4240717991A5061050826 @default.
- W4240717991 hasBestOaLocation W42407179911 @default.
- W4240717991 hasConcept C126189478 @default.
- W4240717991 hasConcept C126322002 @default.
- W4240717991 hasConcept C13373296 @default.
- W4240717991 hasConcept C164027704 @default.
- W4240717991 hasConcept C17991360 @default.
- W4240717991 hasConcept C203014093 @default.
- W4240717991 hasConcept C2776694085 @default.
- W4240717991 hasConcept C2776914184 @default.
- W4240717991 hasConcept C2778239845 @default.
- W4240717991 hasConcept C2778690821 @default.
- W4240717991 hasConcept C2780091579 @default.
- W4240717991 hasConcept C2780404050 @default.
- W4240717991 hasConcept C71924100 @default.
- W4240717991 hasConceptScore W4240717991C126189478 @default.
- W4240717991 hasConceptScore W4240717991C126322002 @default.
- W4240717991 hasConceptScore W4240717991C13373296 @default.
- W4240717991 hasConceptScore W4240717991C164027704 @default.
- W4240717991 hasConceptScore W4240717991C17991360 @default.
- W4240717991 hasConceptScore W4240717991C203014093 @default.
- W4240717991 hasConceptScore W4240717991C2776694085 @default.
- W4240717991 hasConceptScore W4240717991C2776914184 @default.
- W4240717991 hasConceptScore W4240717991C2778239845 @default.
- W4240717991 hasConceptScore W4240717991C2778690821 @default.
- W4240717991 hasConceptScore W4240717991C2780091579 @default.
- W4240717991 hasConceptScore W4240717991C2780404050 @default.
- W4240717991 hasConceptScore W4240717991C71924100 @default.
- W4240717991 hasIssue "6" @default.
- W4240717991 hasLocation W42407179911 @default.
- W4240717991 hasLocation W42407179912 @default.