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• W4240735135 abstract "Abstract Background : Hyperglycemia is an independent predictor of major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS) in 30 days.The purpose of this study is to evaluate the prognostic roles of different glycemic markers for in-hospital MACEs in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI), including hemoglobin A1c (HbA1c) and glycated albumin (GA) and admission blood glucose (ABG). Methods : We conducted a retrospective study with 200 MI patientswho undergone PCI during the hospitalization period. We collected the clinical data and divided all patients into groups based on MACEs.T test and Chi-Square (Fisher) test were conducted to examine the difference between the two groups. Univariate and Multivariate Logistic Analysis and receptor operating curve(ROC) were performed to investigate the prognostic role of each glycemic markers in AMI patients with PCI.Patients were regrouped based on ROC curve and cutoff levels. The Cox regression analysis, Kaplan Meier method and Log rank test was performed for MACEs cumulative events. Results : Among the 200 patients, 18 patients developed MACE. Patients in MACE group had a higherdiastolic blood pressure (DBP) (p=0.019), high-sensitivity troponin T (HS-TnT) peak (p=0.011), CKMB peak (p=0.026),myoglobin (MYO) peak (p=0.006), estimated glomerular filtration rate (eGFR) (p=0.005), low-density lipoprotein cholesterol (LDL-c) (p=0.027),GA(p=0.001) and HbA1c (p=0.010). There were more smokers (p=0.017), diabetic patients (p<0.001) and patients with hypertension(p=0.009) in MACE group. Univariate and Multivariate logistic analysis showed GA (p=0.029) and HbA1c (p=0.048) were independent risk factors of MACEs. ROC curve showed GA had a larger area under the curve (AUC) as prognostic marker of in-hospital MACEs (0.743; 95%confidenceinterval[CI], 0.578-0.907; p=0.001) than HbA1c (0.689; 95%CI, 0.530-0.849; p=0.008) and ABG (0.593; 95%CI, 0.441-0.745; p=0.192).Kaplan Meier curves showed that patients with higher levels of GA (p=0.001), HbA1c (p<0.001) and ABG (p=0.008)had worse clinical events (p=0.001).Univariate and multivariate cox regression analysis presented GA has significant predictive role for MACEs. Conclusion : Among ABG, GA and HbA1c, elevated GA were significant to predict the risk of in-hospital MACEs in AMI patients who undergone PCI during the hospitalization period." @default.
• W4240735135 created "2022-05-12" @default.
• W4240735135 creator A5034552631 @default.
• W4240735135 creator A5037402006 @default.
• W4240735135 date "2020-06-30" @default.
• W4240735135 modified "2023-09-28" @default.
• W4240735135 title "Comparison of Glycated Albumin, Hemoglobin Alc and Admission Blood Glucoseforpredictionof in-hospital Major Adverse Cardiac Events: a Retrospective Study" @default.
• W4240735135 doi "https://doi.org/10.21203/rs.3.rs-37479/v1" @default.
• W4240735135 hasPublicationYear "2020" @default.
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