FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4240746128> ?p ?o ?g. }

• W4240746128 abstract "Background Pharmacological prophylaxis has been proven to reduce the risk of cardiovascular events in patients with atherosclerotic occlusive arterial disease. However, the role of prophylaxis in patients with abdominal aortic aneurysm (AAA) remains unclear. Several studies have shown that despite successful repair, those with AAA have a poorer rate of survival than healthy controls. People with AAA have an increased prevalence of coronary heart disease and risk of cardiovascular events. Despite this association, little is known about the effectiveness of pharmacological prophylaxis in reducing cardiovascular risk in people with AAA. Objectives To determine the long‐term effectiveness of antiplatelet, antihypertensive or lipid‐lowering medication in reducing mortality and cardiovascular events in people with abdominal aortic aneurysm (AAA). Search methods The Cochrane Peripheral Vascular Diseases Group Trials Search Co‐ordinator searched the Specialised Register (last searched April 2013) and CENTRAL (2013, Issue 3). Reference lists of relevant articles were also checked. Selection criteria Randomised controlled trials in which people with AAA were randomly allocated to one prophylactic treatment versus another, a different regimen of the same treatment, a placebo, or no treatment were eligible for inclusion in this review. Primary outcomes included all‐cause mortality and cardiovascular mortality. Data collection and analysis Selection of the studies, quality assessment and data extraction were completed independently by two review authors. Any disagreements were resolved by discussion. Only one study was included in the review, therefore meta‐analysis could not be performed. Main results One randomised controlled study was included in the review. A subgroup of 227 patients with AAA received either metoprolol (N = 111) or placebo (N = 116). There was no clear evidence that metoprolol reduced all‐cause mortality (odds ratio (OR) 0.17, 95% confidence interval (CI) 0.02 to 1.41), cardiovascular death (OR 0.20, 95% CI 0.02 to 1.76), AAA‐related death (OR 1.05, 95% CI 0.06 to 16.92) or increased nonfatal cardiovascular events (OR 1.44, 95% CI 0.58 to 3.57) 30 days postoperatively. Furthermore, at six months postoperatively, estimated effects were compatible with benefit and harm for all‐cause mortality (OR 0.71, 95% CI 0.26 to 1.95), cardiovascular death (OR 0.73, 95% CI 0.23 to 2.39) and nonfatal cardiovascular events (OR 1.41, 95% CI 0.59 to 3.35). Adverse drug effects were reported for the whole study population and were not available for the subgroup of participants with AAA. The study was deemed to be at a generally low risk of bias. Authors' conclusions Due to the limited number of trials, there is insufficient evidence to draw any conclusions about the effectiveness of cardiovascular prophylaxis in reducing mortality and cardiovascular events in people with AAA. Further good‐quality randomised controlled trials examining many types of prophylaxis with long‐term follow‐up are required before firm conclusions can be made." @default.
• W4240746128 created "2022-05-12" @default.
• W4240746128 creator A5000867068 @default.
• W4240746128 creator A5050593836 @default.
• W4240746128 creator A5062500527 @default.
• W4240746128 date "2014-01-21" @default.
• W4240746128 modified "2023-09-28" @default.
• W4240746128 title "Pharmacological treatment of vascular risk factors for reducing mortality and cardiovascular events in patients with abdominal aortic aneurysm" @default.
• W4240746128 cites W1546233327 @default.
• W4240746128 cites W1754836967 @default.
• W4240746128 cites W1910489983 @default.
• W4240746128 cites W1923126167 @default.
• W4240746128 cites W1965702620 @default.
• W4240746128 cites W1971047434 @default.
• W4240746128 cites W1977089095 @default.
• W4240746128 cites W1989160458 @default.
• W4240746128 cites W2002120170 @default.
• W4240746128 cites W2002393226 @default.
• W4240746128 cites W2005040494 @default.
• W4240746128 cites W2007742842 @default.
• W4240746128 cites W2017559656 @default.
• W4240746128 cites W2021202706 @default.
• W4240746128 cites W2023335546 @default.
• W4240746128 cites W2024641271 @default.
• W4240746128 cites W2028182915 @default.
• W4240746128 cites W2030475349 @default.
• W4240746128 cites W2058139826 @default.
• W4240746128 cites W2064995363 @default.
• W4240746128 cites W2065678878 @default.
• W4240746128 cites W2076026971 @default.
• W4240746128 cites W2077523233 @default.
• W4240746128 cites W2081596315 @default.
• W4240746128 cites W2093877908 @default.
• W4240746128 cites W2095115123 @default.
• W4240746128 cites W2103456639 @default.
• W4240746128 cites W2105570905 @default.
• W4240746128 cites W2107312972 @default.
• W4240746128 cites W2122659928 @default.
• W4240746128 cites W2131084209 @default.
• W4240746128 cites W2133335379 @default.
• W4240746128 cites W2137258855 @default.
• W4240746128 cites W2141897673 @default.
• W4240746128 cites W2144623639 @default.
• W4240746128 cites W2146051938 @default.
• W4240746128 cites W2164918202 @default.
• W4240746128 cites W2165636891 @default.
• W4240746128 cites W2166127166 @default.
• W4240746128 cites W2169713883 @default.
• W4240746128 cites W2169721670 @default.
• W4240746128 cites W2317607797 @default.
• W4240746128 cites W2330628369 @default.
• W4240746128 cites W2614781785 @default.
• W4240746128 cites W274148713 @default.
• W4240746128 cites W2887712073 @default.
• W4240746128 cites W3046753755 @default.
• W4240746128 cites W4205946763 @default.
• W4240746128 cites W4234680911 @default.
• W4240746128 cites W4243519354 @default.
• W4240746128 cites W4255146503 @default.
• W4240746128 cites W58432961 @default.
• W4240746128 doi "https://doi.org/10.1002/14651858.cd010447.pub2" @default.
• W4240746128 hasPublicationYear "2014" @default.
• W4240746128 type Work @default.
• W4240746128 citedByCount "4" @default.
• W4240746128 countsByYear W42407461282016 @default.
• W4240746128 countsByYear W42407461282017 @default.
• W4240746128 countsByYear W42407461282018 @default.
• W4240746128 crossrefType "reference-entry" @default.
• W4240746128 hasAuthorship W4240746128A5000867068 @default.
• W4240746128 hasAuthorship W4240746128A5050593836 @default.
• W4240746128 hasAuthorship W4240746128A5062500527 @default.
• W4240746128 hasBestOaLocation W42407461282 @default.
• W4240746128 hasConcept C126322002 @default.
• W4240746128 hasConcept C141071460 @default.
• W4240746128 hasConcept C142724271 @default.
• W4240746128 hasConcept C164705383 @default.
• W4240746128 hasConcept C168563851 @default.
• W4240746128 hasConcept C187960798 @default.
• W4240746128 hasConcept C204787440 @default.
• W4240746128 hasConcept C27081682 @default.
• W4240746128 hasConcept C2776098176 @default.
• W4240746128 hasConcept C2777323849 @default.
• W4240746128 hasConcept C2779134260 @default.
• W4240746128 hasConcept C2779993416 @default.
• W4240746128 hasConcept C2781413609 @default.
• W4240746128 hasConcept C71924100 @default.
• W4240746128 hasConcept C95190672 @default.
• W4240746128 hasConceptScore W4240746128C126322002 @default.
• W4240746128 hasConceptScore W4240746128C141071460 @default.
• W4240746128 hasConceptScore W4240746128C142724271 @default.
• W4240746128 hasConceptScore W4240746128C164705383 @default.
• W4240746128 hasConceptScore W4240746128C168563851 @default.
• W4240746128 hasConceptScore W4240746128C187960798 @default.
• W4240746128 hasConceptScore W4240746128C204787440 @default.
• W4240746128 hasConceptScore W4240746128C27081682 @default.
• W4240746128 hasConceptScore W4240746128C2776098176 @default.
• W4240746128 hasConceptScore W4240746128C2777323849 @default.
• W4240746128 hasConceptScore W4240746128C2779134260 @default.
• W4240746128 hasConceptScore W4240746128C2779993416 @default.
• W4240746128 hasConceptScore W4240746128C2781413609 @default.

• next