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- W4240775650 abstract "Publisher SummaryPlatelet dumps and individual platelets have been visualized in the intact circulation of mammals by Bizzozero and Algire, who found that the circulating platelet is round or lancet shaped and without processes. These findings are supported by in vitro experiments. The variety of shapes that the platelet may assume in coverslip preparations depends on the thickness of the preparation, the surface property of the glass, the anticoagulant used and its concentration. Probably variation of other factors, such as pH, ionic strength, and temperature, would also influence platelet morphology. It appears not unlikely that at least part of these changes in platelet morphology is brought about by membrane phenomena and ionic exchanges that may be akin to the swelling, hemolysis, crenation, and sickling of red cells. Possibly further studies along these lines may throw some light on the properties of the platelet surface. The importance of interface phenomena for platelet morphology has been stressed by Ferguson. The addition of anticoagulants in the usual concentrations and amounts changes platelet morphology so markedly that it becomes unlikely that morphologic changes can be considered representative of platelet behavior during the clotting process as suggested by Fonio." @default.
- W4240775650 created "2022-05-12" @default.
- W4240775650 date "2000-01-01" @default.
- W4240775650 modified "2023-09-28" @default.
- W4240775650 title "Commentary on and reprint of Brecher G, Cronkite EP, Morphology and enumeration of human blood platelets, in Journal of Applied Physiology (1950) 3:365–377" @default.
- W4240775650 doi "https://doi.org/10.1016/b978-012448510-5.50173-4" @default.
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