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- W4240781423 abstract "Front cover: Phospho-tau antibodies are the most common tool for detecting site-specific tau phosphorylation. However, there is no quantitative measure of specificity that guides users. We developed a robust flow cytometry assay that determines a specificity parameter termed ϕ(phi), which measures the fraction of non-specific signal in antibody binding. We applied the assay to measure the specificity of widely used phospho-tau antibodies, and show that phospho-tau antibodies AT8, AT180, PHF-6, TG-3, and PHF-1 have nearly perfect specificity. Image content: Representative confocal image showing highly specific recognition of tau phosphorylated at Thr231 (red) among total tau (green), imaged using EGFP-tau. Read the full preface ‘High specificity of widely used phospho-tau antibodies validated using a quantitative wholecell based assay’ by D. Li, Y. K. Cho (J. Neurochem. 2020, vol. 152 (1), pp. 122–135) on doi: 10.1111/jnc.14830" @default.
- W4240781423 created "2022-05-12" @default.
- W4240781423 date "2020-01-01" @default.
- W4240781423 modified "2023-10-05" @default.
- W4240781423 doi "https://doi.org/10.1111/jnc.v152.1" @default.
- W4240781423 hasPublicationYear "2020" @default.
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