Matches in SemOpenAlex for { <https://semopenalex.org/work/W4240789788> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4240789788 abstract "Abstract Status epilepticus (SE) develops from abnormal electrical discharges, resulting in neuronal damage. Current treatments include antiepileptic drugs. However, the most common drugs used to treat seizures may sometimes be ineffective and have many side effects. Melatonin is an endogenous physiological hormone that is considered an alternative treatment for neurological disorders because of its free radical scavenging property. Thus, this study aimed to determine the effects of melatonin pretreatment on SE by inducing glutamatergic hyperstimulation in zebrafish. Seizures were induced in zebrafish using kainic acid (KA), a glutamate analog, and the seizure intensity was recorded for 60 min. Melatonin treatment for 7 days showed a decrease in seizure intensity (28%), latency to reach score 5 (14 min), and duration of SE (29%). In addition, melatonin treatment attenuated glutamate transporter levels, which significantly decreased in the zebrafish brain after 12 h of KA-induced seizures. Melatonin treatment reduced the increase in oxidative stress by reactive oxygen species formation through thiobarbituric acid reactive substances and 2‘,7‘-dichiorofluorescin, induced by KA-seizure. An imbalance of antioxidant enzyme activities such as superoxide dismutase and catalase was influenced by melatonin and KA-induced seizures. Our study indicates that melatonin promotes a neuroprotective response against the epileptic profile in zebrafish. These effects could be related to the modulation of glutamatergic neurotransmission, recovery of glutamate uptake, and oxidative stress parameters in the zebrafish brain." @default.
- W4240789788 created "2022-05-12" @default.
- W4240789788 creator A5030380438 @default.
- W4240789788 creator A5049505863 @default.
- W4240789788 creator A5059046257 @default.
- W4240789788 creator A5066731830 @default.
- W4240789788 creator A5068499405 @default.
- W4240789788 creator A5082431414 @default.
- W4240789788 date "2021-06-17" @default.
- W4240789788 modified "2023-09-27" @default.
- W4240789788 title "Melatonin Pretreatment Protects Against Status Epilepticus, Glutamate Transport, and Oxidative Stress Induced by Kainic Acid in Zebrafish" @default.
- W4240789788 doi "https://doi.org/10.21203/rs.3.rs-611477/v1" @default.
- W4240789788 hasPublicationYear "2021" @default.
- W4240789788 type Work @default.
- W4240789788 citedByCount "0" @default.
- W4240789788 crossrefType "posted-content" @default.
- W4240789788 hasAuthorship W4240789788A5030380438 @default.
- W4240789788 hasAuthorship W4240789788A5049505863 @default.
- W4240789788 hasAuthorship W4240789788A5059046257 @default.
- W4240789788 hasAuthorship W4240789788A5066731830 @default.
- W4240789788 hasAuthorship W4240789788A5068499405 @default.
- W4240789788 hasAuthorship W4240789788A5082431414 @default.
- W4240789788 hasBestOaLocation W42407897881 @default.
- W4240789788 hasConcept C104317684 @default.
- W4240789788 hasConcept C126322002 @default.
- W4240789788 hasConcept C134018914 @default.
- W4240789788 hasConcept C169760540 @default.
- W4240789788 hasConcept C170493617 @default.
- W4240789788 hasConcept C185592680 @default.
- W4240789788 hasConcept C25498285 @default.
- W4240789788 hasConcept C2775838275 @default.
- W4240789788 hasConcept C2776108384 @default.
- W4240789788 hasConcept C2776108821 @default.
- W4240789788 hasConcept C2776151105 @default.
- W4240789788 hasConcept C2776878037 @default.
- W4240789788 hasConcept C2777341932 @default.
- W4240789788 hasConcept C2778182776 @default.
- W4240789788 hasConcept C2778186239 @default.
- W4240789788 hasConcept C2780648746 @default.
- W4240789788 hasConcept C2781012912 @default.
- W4240789788 hasConcept C55493867 @default.
- W4240789788 hasConcept C61174792 @default.
- W4240789788 hasConcept C71924100 @default.
- W4240789788 hasConcept C86803240 @default.
- W4240789788 hasConcept C98274493 @default.
- W4240789788 hasConceptScore W4240789788C104317684 @default.
- W4240789788 hasConceptScore W4240789788C126322002 @default.
- W4240789788 hasConceptScore W4240789788C134018914 @default.
- W4240789788 hasConceptScore W4240789788C169760540 @default.
- W4240789788 hasConceptScore W4240789788C170493617 @default.
- W4240789788 hasConceptScore W4240789788C185592680 @default.
- W4240789788 hasConceptScore W4240789788C25498285 @default.
- W4240789788 hasConceptScore W4240789788C2775838275 @default.
- W4240789788 hasConceptScore W4240789788C2776108384 @default.
- W4240789788 hasConceptScore W4240789788C2776108821 @default.
- W4240789788 hasConceptScore W4240789788C2776151105 @default.
- W4240789788 hasConceptScore W4240789788C2776878037 @default.
- W4240789788 hasConceptScore W4240789788C2777341932 @default.
- W4240789788 hasConceptScore W4240789788C2778182776 @default.
- W4240789788 hasConceptScore W4240789788C2778186239 @default.
- W4240789788 hasConceptScore W4240789788C2780648746 @default.
- W4240789788 hasConceptScore W4240789788C2781012912 @default.
- W4240789788 hasConceptScore W4240789788C55493867 @default.
- W4240789788 hasConceptScore W4240789788C61174792 @default.
- W4240789788 hasConceptScore W4240789788C71924100 @default.
- W4240789788 hasConceptScore W4240789788C86803240 @default.
- W4240789788 hasConceptScore W4240789788C98274493 @default.
- W4240789788 hasLocation W42407897881 @default.
- W4240789788 hasOpenAccess W4240789788 @default.
- W4240789788 hasPrimaryLocation W42407897881 @default.
- W4240789788 hasRelatedWork W1966560646 @default.
- W4240789788 hasRelatedWork W1976784386 @default.
- W4240789788 hasRelatedWork W2044433533 @default.
- W4240789788 hasRelatedWork W2049958331 @default.
- W4240789788 hasRelatedWork W2122511490 @default.
- W4240789788 hasRelatedWork W2314540945 @default.
- W4240789788 hasRelatedWork W2802751241 @default.
- W4240789788 hasRelatedWork W3171576726 @default.
- W4240789788 hasRelatedWork W3212146879 @default.
- W4240789788 hasRelatedWork W4240789788 @default.
- W4240789788 isParatext "false" @default.
- W4240789788 isRetracted "false" @default.
- W4240789788 workType "article" @default.