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- W4240795172 abstract "Abstract Background Diabetes during pregnancy affects placental mitochondrial content and function, which can impact fetal development and the long-term health of offspring. Resistin is a peptide hormone originally discovered in mice as an adipocyte-derived factor that induced insulin resistance. Unlike rodents, human resistin is primarily secreted by monocytes or macrophages. The regulation and roles of human resistin in diabetes during pregnancy remain unclear. Methods Human resistin levels were measured in cord blood of women with diabetes during pregnancy (n=42) and healthy controls (n=81). Secretion of resistin from cord blood mononuclear cells (CBMCs) were measured. The actions of human resistin in mitochondrial biogenesis were determined on placental trophoblastic cells (BeWo cells) or human placental explant. Results Concentrations of human resistin in cord sera were higher in diabetic pregnancies (67 ng/ml) compared to healthy controls (50 ng/ml, P< 0.05), and correlated (r=0.4, P=0.002) with a measure of maternal glycemia (glucose concentration 2 h post challenge). Resistin mRNA was most abundant in cord blood mononuclear cells (CBMCs). Secretion of resistin from cultured CBMCs was increased in response to high glucose (25 mM). Exposing BeWo cells or human placental explant to resistin decreased expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), mitochondrial abundance, and ATP production. Conclusions In summary, we have shown that resistin is increased in fetal circulation of infants exposed to the diabetic milieu potentially reflecting the response of monocytes/macrophages to hyperglycemia and metabolic stresses associated with diabetes during pregnancy. Increased exposure to resistin may contribute to mitochondrial dysfunction and aberrant energy metabolism characteristic of offspring exposed to diabetes in utero ." @default.
- W4240795172 created "2022-05-12" @default.
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- W4240795172 date "2020-03-27" @default.
- W4240795172 modified "2023-09-27" @default.
- W4240795172 title "Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis" @default.
- W4240795172 doi "https://doi.org/10.21203/rs.3.rs-19051/v1" @default.
- W4240795172 hasPublicationYear "2020" @default.
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