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- W4240796531 abstract "Fibroblasts from a particular patient with Lesch-Nyhan syndrome developed full resistance to aminopterin, in association with a progressive increase in 3H-hypoxanthine incorporation. This represented a gradual and generalized adaptation. When aminopterin treatment was stopped, the minimal 3H-hypoxanthine uptake of untreated cells was re-established. The hypoxanthine-guanine phosphoribosyltransferase activity of extracts of these cells was as low as in other Lesch-Nyhan cultures, but aminopterin-treated cells contained more than twice as much activity, suggesting that an increased amount of enzyme caused the adaptation. However, this conlusion can only be tentative in view of the complex and circular nature of the interconversions of hypoxanthine, inosine and inosinic acid in these extracts." @default.
- W4240796531 created "2022-05-12" @default.
- W4240796531 date "1988-09-01" @default.
- W4240796531 modified "2023-10-16" @default.
- W4240796531 title "Author index volume 68 (1988)" @default.
- W4240796531 doi "https://doi.org/10.1016/0378-1119(88)90039-x" @default.
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