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• W4240807040 abstract "In Brief Objective To find whether pulse pressure, a measure of arterial compliance, is associated early in pregnancy with increased risk of developing preeclampsia. Methods In a prospective cohort of 576 nulliparas, we examined blood pressures throughout pregnancy and at 6–8 weeks postpartum. Measurements during weeks 7–15, 16–24, and 25–38 of gestation were pooled to find averages for each period. Outcomes assessed were gestational hypertension and preeclampsia. Logistic regression analysis was used to develop relative risks and 95% confidence intervals. Results We confirmed 34 (5.9%) cases of preeclampsia, 32 (5.6%) cases of gestational hypertension, and 510 normotensive women. Mean systolic and diastolic blood pressures and mean arterial pressures were elevated throughout pregnancy in women who developed hypertensive disorders of pregnancy compared with normotensive women. Pulse pressure at 7–15 weeks was significantly higher in women who developed preeclampsia (45 ± 6 mmHg) than in those who developed gestational hypertension (41 ± 7 mmHg, P = .03) and normotensive women (41 ± 8 mmHg, P = .01). Examined in tertiles, increasing pulse pressure was associated with increasing risk of developing preeclampsia (P for trend = .01) but not gestational hypertension (P for trend = .95). After adjustment for potential confounders, a 1-mmHg rise in early pregnancy pulse pressure was associated with a 6% (95% confidence interval: 1, 10) increase in risk for developing preeclampsia but not gestational hypertension (relative risk: 1%; 95% confidence interval: −1, 6). Beyond 15 weeks' gestation, differences between groups diminished, but women with any hypertensive disorder had higher pulse pressures than women with uncomplicated pregnancies. Conclusion Elevated pulse pressure, indicating poor arterial compliance, was evident early in pregnancies of women who subsequently developed preeclampsia. Pulse pressure, a marker of arterial compliance, is altered early in pregnancies of women who subsequently develop preeclampsia." @default.
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• W4240807040 date "2001-04-01" @default.
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• W4240807040 title "Pulse Pressure and Risk of Preeclampsia" @default.
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• W4240807040 doi "https://doi.org/10.1097/00006250-200104000-00007" @default.
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