Matches in SemOpenAlex for { <https://semopenalex.org/work/W4240969110> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4240969110 endingPage "S65" @default.
- W4240969110 startingPage "S64" @default.
- W4240969110 abstract "The production of reactive oxygen species (ROS) via the oxidative burst has been connected with promotion of inflammation and tissue damage, but in recent years has been implicated in regulation and resolution of inflammation. The aim of this project was to elucidate the impact of the oxidative burst on the development of lupus-like autoimmunity. Lupus was induced by with pristane oil. Ex vivo phagocytosis assays were deployed to assess the uptake of cell debris in ROS deficient mice. The formation of neutrophil extracellular traps (NETs) was analysed by immune fluorescence microscopy. ROS activators were injected into mice to investigate the possible beneficial clinical effects on lupus pathology. Determine the effects neutrophil serine proteases have on the degradation of inflammatory mediators The absence of ROS gives rise to dramatically exacerbated lupus. Aberrant phagocytosis in ROS-deficient animals leading to production of inflammatory mediators, accompanied by diminished pristane-induced but higher spontaneous formation of NETs could be responsible for this phenotype. Treatment with NOX2 agonists ameliorated the clinical course in mice, while application of a ROS scavenger worsened disease outcome." @default.
- W4240969110 created "2022-05-12" @default.
- W4240969110 creator A5004053109 @default.
- W4240969110 creator A5004556215 @default.
- W4240969110 creator A5010629312 @default.
- W4240969110 creator A5014353054 @default.
- W4240969110 creator A5019620317 @default.
- W4240969110 creator A5042440539 @default.
- W4240969110 creator A5044332195 @default.
- W4240969110 creator A5045847121 @default.
- W4240969110 creator A5050601865 @default.
- W4240969110 creator A5061814144 @default.
- W4240969110 creator A5065010462 @default.
- W4240969110 creator A5070484568 @default.
- W4240969110 creator A5073878586 @default.
- W4240969110 creator A5075261558 @default.
- W4240969110 creator A5077974128 @default.
- W4240969110 creator A5079719869 @default.
- W4240969110 creator A5087485883 @default.
- W4240969110 creator A5089123738 @default.
- W4240969110 date "2018-05-01" @default.
- W4240969110 modified "2023-10-17" @default.
- W4240969110 title "ROS is the boss" @default.
- W4240969110 doi "https://doi.org/10.1016/j.freeradbiomed.2018.04.213" @default.
- W4240969110 hasPublicationYear "2018" @default.
- W4240969110 type Work @default.
- W4240969110 citedByCount "0" @default.
- W4240969110 crossrefType "journal-article" @default.
- W4240969110 hasAuthorship W4240969110A5004053109 @default.
- W4240969110 hasAuthorship W4240969110A5004556215 @default.
- W4240969110 hasAuthorship W4240969110A5010629312 @default.
- W4240969110 hasAuthorship W4240969110A5014353054 @default.
- W4240969110 hasAuthorship W4240969110A5019620317 @default.
- W4240969110 hasAuthorship W4240969110A5042440539 @default.
- W4240969110 hasAuthorship W4240969110A5044332195 @default.
- W4240969110 hasAuthorship W4240969110A5045847121 @default.
- W4240969110 hasAuthorship W4240969110A5050601865 @default.
- W4240969110 hasAuthorship W4240969110A5061814144 @default.
- W4240969110 hasAuthorship W4240969110A5065010462 @default.
- W4240969110 hasAuthorship W4240969110A5070484568 @default.
- W4240969110 hasAuthorship W4240969110A5073878586 @default.
- W4240969110 hasAuthorship W4240969110A5075261558 @default.
- W4240969110 hasAuthorship W4240969110A5077974128 @default.
- W4240969110 hasAuthorship W4240969110A5079719869 @default.
- W4240969110 hasAuthorship W4240969110A5087485883 @default.
- W4240969110 hasAuthorship W4240969110A5089123738 @default.
- W4240969110 hasConcept C134897094 @default.
- W4240969110 hasConcept C142724271 @default.
- W4240969110 hasConcept C160448771 @default.
- W4240969110 hasConcept C185592680 @default.
- W4240969110 hasConcept C203014093 @default.
- W4240969110 hasConcept C2776151105 @default.
- W4240969110 hasConcept C2776912625 @default.
- W4240969110 hasConcept C2776914184 @default.
- W4240969110 hasConcept C2779134260 @default.
- W4240969110 hasConcept C2780130043 @default.
- W4240969110 hasConcept C48349386 @default.
- W4240969110 hasConcept C55493867 @default.
- W4240969110 hasConcept C71924100 @default.
- W4240969110 hasConcept C86803240 @default.
- W4240969110 hasConcept C8891405 @default.
- W4240969110 hasConcept C95444343 @default.
- W4240969110 hasConcept C99971728 @default.
- W4240969110 hasConceptScore W4240969110C134897094 @default.
- W4240969110 hasConceptScore W4240969110C142724271 @default.
- W4240969110 hasConceptScore W4240969110C160448771 @default.
- W4240969110 hasConceptScore W4240969110C185592680 @default.
- W4240969110 hasConceptScore W4240969110C203014093 @default.
- W4240969110 hasConceptScore W4240969110C2776151105 @default.
- W4240969110 hasConceptScore W4240969110C2776912625 @default.
- W4240969110 hasConceptScore W4240969110C2776914184 @default.
- W4240969110 hasConceptScore W4240969110C2779134260 @default.
- W4240969110 hasConceptScore W4240969110C2780130043 @default.
- W4240969110 hasConceptScore W4240969110C48349386 @default.
- W4240969110 hasConceptScore W4240969110C55493867 @default.
- W4240969110 hasConceptScore W4240969110C71924100 @default.
- W4240969110 hasConceptScore W4240969110C86803240 @default.
- W4240969110 hasConceptScore W4240969110C8891405 @default.
- W4240969110 hasConceptScore W4240969110C95444343 @default.
- W4240969110 hasConceptScore W4240969110C99971728 @default.
- W4240969110 hasLocation W42409691101 @default.
- W4240969110 hasOpenAccess W4240969110 @default.
- W4240969110 hasPrimaryLocation W42409691101 @default.
- W4240969110 hasRelatedWork W1673047673 @default.
- W4240969110 hasRelatedWork W1994113916 @default.
- W4240969110 hasRelatedWork W2418559667 @default.
- W4240969110 hasRelatedWork W2905201612 @default.
- W4240969110 hasRelatedWork W3014780274 @default.
- W4240969110 hasRelatedWork W3042528270 @default.
- W4240969110 hasRelatedWork W3128352328 @default.
- W4240969110 hasRelatedWork W4224949235 @default.
- W4240969110 hasRelatedWork W4386396259 @default.
- W4240969110 hasRelatedWork W60633371 @default.
- W4240969110 hasVolume "120" @default.
- W4240969110 isParatext "false" @default.
- W4240969110 isRetracted "false" @default.
- W4240969110 workType "article" @default.