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- W4240982009 abstract "The regulation of acid–base balance in the body underlies the importance of pH in a variety of cellular and subcellular biological functions; for example, regulation of protein synthesis and intermediate carbohydrate metabolism are pH-sensitive processes. Clinically, this is apparent by the failure to grow normally in an acidemic environment and explains an increase in anaerobic glycolysis in alkalemia, due to an increase in a rate-limiting step of glycolysis phosphofructokinase-l. pH is important in numerous transport functions across membranes, such as increasing acid extrusion from cells when cellular pH drops. In general, cellular pH is lower than extracellular pH related to the electronegativity within cellular structures. The delivery of oxygen to tissues such as the brain and skeletal muscle is very much dependent on extracellular pH via the shift in the oxyhemoglobin dissociation curve." @default.
- W4240982009 created "2022-05-12" @default.
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- W4240982009 date "2014-07-01" @default.
- W4240982009 modified "2023-09-27" @default.
- W4240982009 title "Electrolyte Disorders" @default.
- W4240982009 doi "https://doi.org/10.1093/med/9780199358274.003.0058" @default.
- W4240982009 hasPublicationYear "2014" @default.
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