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- W4241018210 abstract "DNA synthesis in mouse strain-L fibroblasts was inhibited following exposure to ultraviolet light or puromycin. The effect produced with small doses of ultraviolet light was temporary, maximum inhibition being observed 5–8 h after irradiation. The data obtained following puromycin treatment are compatible with the hypothesis that protein synthesis is a prerequisite for DNA synthesis in L cells. Despite the marked depression in intracellular DNA synthesis observed 5–8 h after these treatments, virtually no inhibition of the phosphorylation of thymidine to thymidine triphosphate or the activity of DNA polymerase could be detected at the same time. The phosphorylation of thymidine to thymidine triphosphate does not appear to be of primary importance in the regulation of DNA synthesis in these cells." @default.
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- W4241018210 date "1962-06-01" @default.
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- W4241018210 title "The effects of ultraviolet irradiation and inhibitors of protein synthesis on the initiation of deoxyribonucleic acid synthesis in mammalian cells in culture II. Effects on the phosphorylation of thymidine" @default.
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- W4241018210 doi "https://doi.org/10.1016/0926-6550(62)90356-0" @default.
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