FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4241033554> ?p ?o ?g. }

• W4241033554 endingPage "1426" @default.
• W4241033554 startingPage "1422" @default.
• W4241033554 abstract "The Krüppel-associated box (KRAB) domain, originally identified as a 75-aa sequence present in numerous Krüppel-type zinc-finger proteins, is a potent DNA-binding-dependent transcriptional repression domain that is believed to function through interaction with the transcriptional intermediary factor 1 (TIF1) β. On the basis of sequence comparison and phylogenetic analysis, we have recently defined three distinct subfamilies of KRAB domains. In the present study, individual members of each subfamily were tested for transcriptional repression and interaction with TIF1β and two other closely related family members (TIF1α and TIF1γ). All KRAB variants were shown, ( i ) to repress transcription when targeted to DNA through fusion to a heterologous DNA-binding domain in mammalian cells, and ( ii ) to interact specifically with TIF1β, but not with TIF1α or TIF1γ. Taken together, these results implicate TIF1β as a common transcriptional corepressor for the three distinct subfamilies of KRAB zinc-finger proteins and suggest a high degree of conservation in the molecular mechanism underlying their transcriptional repression activity." @default.
• W4241033554 created "2022-05-12" @default.
• W4241033554 creator A5012079907 @default.
• W4241033554 creator A5023032556 @default.
• W4241033554 creator A5024492052 @default.
• W4241033554 creator A5036428126 @default.
• W4241033554 creator A5070310428 @default.
• W4241033554 creator A5071968898 @default.
• W4241033554 creator A5084694876 @default.
• W4241033554 creator A5085761422 @default.
• W4241033554 date "2001-02-06" @default.
• W4241033554 modified "2023-10-18" @default.
• W4241033554 title "Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1 β" @default.
• W4241033554 cites W1487669901 @default.
• W4241033554 cites W1488915620 @default.
• W4241033554 cites W1625510017 @default.
• W4241033554 cites W1791571505 @default.
• W4241033554 cites W1900275723 @default.
• W4241033554 cites W1971389840 @default.
• W4241033554 cites W1974314527 @default.
• W4241033554 cites W1982462516 @default.
• W4241033554 cites W1986335988 @default.
• W4241033554 cites W1991125055 @default.
• W4241033554 cites W2004581607 @default.
• W4241033554 cites W2004705005 @default.
• W4241033554 cites W2005035809 @default.
• W4241033554 cites W2016818916 @default.
• W4241033554 cites W2021484656 @default.
• W4241033554 cites W2052808935 @default.
• W4241033554 cites W2055043322 @default.
• W4241033554 cites W2056793372 @default.
• W4241033554 cites W2063904948 @default.
• W4241033554 cites W2082579696 @default.
• W4241033554 cites W2085630342 @default.
• W4241033554 cites W2088335689 @default.
• W4241033554 cites W2094049721 @default.
• W4241033554 cites W2106109160 @default.
• W4241033554 cites W2110576677 @default.
• W4241033554 cites W2142529970 @default.
• W4241033554 cites W2152326948 @default.
• W4241033554 cites W2158074993 @default.
• W4241033554 cites W2160402926 @default.
• W4241033554 doi "https://doi.org/10.1073/pnas.98.4.1422" @default.
• W4241033554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11171966" @default.
• W4241033554 hasPublicationYear "2001" @default.
• W4241033554 type Work @default.
• W4241033554 citedByCount "24" @default.
• W4241033554 countsByYear W42410335542015 @default.
• W4241033554 countsByYear W42410335542016 @default.
• W4241033554 countsByYear W42410335542017 @default.
• W4241033554 countsByYear W42410335542019 @default.
• W4241033554 countsByYear W42410335542022 @default.
• W4241033554 crossrefType "journal-article" @default.
• W4241033554 hasAuthorship W4241033554A5012079907 @default.
• W4241033554 hasAuthorship W4241033554A5023032556 @default.
• W4241033554 hasAuthorship W4241033554A5024492052 @default.
• W4241033554 hasAuthorship W4241033554A5036428126 @default.
• W4241033554 hasAuthorship W4241033554A5070310428 @default.
• W4241033554 hasAuthorship W4241033554A5071968898 @default.
• W4241033554 hasAuthorship W4241033554A5084694876 @default.
• W4241033554 hasAuthorship W4241033554A5085761422 @default.
• W4241033554 hasBestOaLocation W42410335541 @default.
• W4241033554 hasConcept C101762097 @default.
• W4241033554 hasConcept C104317684 @default.
• W4241033554 hasConcept C146777309 @default.
• W4241033554 hasConcept C150194340 @default.
• W4241033554 hasConcept C158448853 @default.
• W4241033554 hasConcept C186055190 @default.
• W4241033554 hasConcept C186310378 @default.
• W4241033554 hasConcept C24284526 @default.
• W4241033554 hasConcept C27153228 @default.
• W4241033554 hasConcept C2781435330 @default.
• W4241033554 hasConcept C33987129 @default.
• W4241033554 hasConcept C3662595 @default.
• W4241033554 hasConcept C50929876 @default.
• W4241033554 hasConcept C5432534 @default.
• W4241033554 hasConcept C54355233 @default.
• W4241033554 hasConcept C552990157 @default.
• W4241033554 hasConcept C86339819 @default.
• W4241033554 hasConcept C86803240 @default.
• W4241033554 hasConceptScore W4241033554C101762097 @default.
• W4241033554 hasConceptScore W4241033554C104317684 @default.
• W4241033554 hasConceptScore W4241033554C146777309 @default.
• W4241033554 hasConceptScore W4241033554C150194340 @default.
• W4241033554 hasConceptScore W4241033554C158448853 @default.
• W4241033554 hasConceptScore W4241033554C186055190 @default.
• W4241033554 hasConceptScore W4241033554C186310378 @default.
• W4241033554 hasConceptScore W4241033554C24284526 @default.
• W4241033554 hasConceptScore W4241033554C27153228 @default.
• W4241033554 hasConceptScore W4241033554C2781435330 @default.
• W4241033554 hasConceptScore W4241033554C33987129 @default.
• W4241033554 hasConceptScore W4241033554C3662595 @default.
• W4241033554 hasConceptScore W4241033554C50929876 @default.
• W4241033554 hasConceptScore W4241033554C5432534 @default.
• W4241033554 hasConceptScore W4241033554C54355233 @default.
• W4241033554 hasConceptScore W4241033554C552990157 @default.
• W4241033554 hasConceptScore W4241033554C86339819 @default.
• W4241033554 hasConceptScore W4241033554C86803240 @default.

• next