Matches in SemOpenAlex for { <https://semopenalex.org/work/W4241094998> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4241094998 endingPage "e296" @default.
- W4241094998 startingPage "e296" @default.
- W4241094998 abstract "Repeated brief seizures, such as those induced by electroconvulsive therapy (ECT), markedly elevate neurotrophic factor levels in the adult rat brain, but it is not known whether a similar response to seizures occurs in immature animals. To address this question, we evoked brief seizures with electroconvulsive shock (ECS) in rat pups at different stages of postnatal development and examined basic fibroblast growth factor (FGF-2), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) proteins in selected brain regions in which these trophic factors are known to increase in the adult rat following ECS-induced seizures.ECS treatments were administered daily (3 episodes/day) over 7 days to rat pups of three different ages: postnatal day (P)1–7, P7–13, or P14–20. Protein levels were measured 6 h after the last ECS using Western blotting for FGF-2 in rhinal cortex, ELISA for BDNF and NGF in hippocampus, and NGF in frontal cortex.7 days of repeated ECS-induced seizures during P1–7 did not alter protein levels for BDNF, FGF-2, or NGF. The repeated seizures during P7–13 affected only BDNF protein, causing a significant elevation of 40% in hippocampus over sham-treated controls. In P14–20 pups, the repeated seizures resulted in a significant increase in BDNF in hippocampus (162% over controls) and FGF-2 in rhinal cortex (34% over controls), while NGF protein did not show a significant change in either hippocampus or frontal cortex.The results suggest that during the first postnatal week there is a resistance to seizure-induced increase in neurotrophic factors, but by the third postnatal week, both BDNF and FGF-2 are elevated substantially in response to repeated seizures. This time-dependent profile suggests that synthesis of these proteins is initially activity-independent, becoming subject to activity-dependent regulation by 3 weeks of age. This maturation of seizure-evoked changes in trophic factors may be important for understanding the impact of ECT and seizures in childhood." @default.
- W4241094998 created "2022-05-12" @default.
- W4241094998 creator A5002706827 @default.
- W4241094998 creator A5008957497 @default.
- W4241094998 creator A5025557961 @default.
- W4241094998 creator A5026627576 @default.
- W4241094998 creator A5029475928 @default.
- W4241094998 creator A5030242147 @default.
- W4241094998 date "2011-09-01" @default.
- W4241094998 modified "2023-09-29" @default.
- W4241094998 title "The effects of zinc administration on seizure-induced aberrant neurogenesis in hippocampal dentate gyrus" @default.
- W4241094998 doi "https://doi.org/10.1016/j.neures.2011.07.1291" @default.
- W4241094998 hasPublicationYear "2011" @default.
- W4241094998 type Work @default.
- W4241094998 citedByCount "0" @default.
- W4241094998 crossrefType "journal-article" @default.
- W4241094998 hasAuthorship W4241094998A5002706827 @default.
- W4241094998 hasAuthorship W4241094998A5008957497 @default.
- W4241094998 hasAuthorship W4241094998A5025557961 @default.
- W4241094998 hasAuthorship W4241094998A5026627576 @default.
- W4241094998 hasAuthorship W4241094998A5029475928 @default.
- W4241094998 hasAuthorship W4241094998A5030242147 @default.
- W4241094998 hasConcept C126322002 @default.
- W4241094998 hasConcept C134018914 @default.
- W4241094998 hasConcept C148762608 @default.
- W4241094998 hasConcept C15744967 @default.
- W4241094998 hasConcept C160539049 @default.
- W4241094998 hasConcept C169760540 @default.
- W4241094998 hasConcept C170493617 @default.
- W4241094998 hasConcept C2776464000 @default.
- W4241094998 hasConcept C2778423431 @default.
- W4241094998 hasConcept C2778790584 @default.
- W4241094998 hasConcept C2781161787 @default.
- W4241094998 hasConcept C4746552 @default.
- W4241094998 hasConcept C71924100 @default.
- W4241094998 hasConcept C92020748 @default.
- W4241094998 hasConceptScore W4241094998C126322002 @default.
- W4241094998 hasConceptScore W4241094998C134018914 @default.
- W4241094998 hasConceptScore W4241094998C148762608 @default.
- W4241094998 hasConceptScore W4241094998C15744967 @default.
- W4241094998 hasConceptScore W4241094998C160539049 @default.
- W4241094998 hasConceptScore W4241094998C169760540 @default.
- W4241094998 hasConceptScore W4241094998C170493617 @default.
- W4241094998 hasConceptScore W4241094998C2776464000 @default.
- W4241094998 hasConceptScore W4241094998C2778423431 @default.
- W4241094998 hasConceptScore W4241094998C2778790584 @default.
- W4241094998 hasConceptScore W4241094998C2781161787 @default.
- W4241094998 hasConceptScore W4241094998C4746552 @default.
- W4241094998 hasConceptScore W4241094998C71924100 @default.
- W4241094998 hasConceptScore W4241094998C92020748 @default.
- W4241094998 hasLocation W42410949981 @default.
- W4241094998 hasOpenAccess W4241094998 @default.
- W4241094998 hasPrimaryLocation W42410949981 @default.
- W4241094998 hasRelatedWork W1581458838 @default.
- W4241094998 hasRelatedWork W1965065729 @default.
- W4241094998 hasRelatedWork W1979782640 @default.
- W4241094998 hasRelatedWork W1993681982 @default.
- W4241094998 hasRelatedWork W2059093737 @default.
- W4241094998 hasRelatedWork W2081792644 @default.
- W4241094998 hasRelatedWork W2111443630 @default.
- W4241094998 hasRelatedWork W2140612587 @default.
- W4241094998 hasRelatedWork W2604440697 @default.
- W4241094998 hasRelatedWork W4225680454 @default.
- W4241094998 hasVolume "71" @default.
- W4241094998 isParatext "false" @default.
- W4241094998 isRetracted "false" @default.
- W4241094998 workType "article" @default.