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- W4241155704 abstract "Polychlorinated dibenzofurans (PCDFs) may be formed by combustion of chlorinated aromatic compounds and may be present as contaminants in aromatic chlorinated commercial products. There is some evidence that they can also be formed by bacteria. In the environment they are usually found with other chlorinated compounds, such as the polychlorinated dibenzo-p-dioxins (PCDDs). To facilitate the interpretation of results of environmental and human monitoring data, toxic equivalency factors (TEFs) have been developed for individual congeners of PCDDs and PCDFs relative to the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. It is unclear how well the practice of adding these factors reflects the toxicity of a chemical mixture in different species. PCDFs have not been extensively studied. Toxicity in different animal species varies greatly and so do target organs. Humans, like resistant mouse strains, are not as susceptible to the toxic effects of these compounds. Toxicity is in part mediated through the aryl hydrocarbon receptor (AHR). The amino acid sequence of the human and murine AHR of resistant mice responsible for the reduced ligand-binding affinity of the AHR is the same in both species. Two poisoning outbreaks occurred in Japan and Taiwan in 1968 and 1978 when cooking oil became contaminated with PCDFs, PCDDs, polychlorinated biphenyls (PCBs), and quaterphenyls (PCQs)." @default.
- W4241155704 created "2022-05-12" @default.
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- W4241155704 date "2014-01-01" @default.
- W4241155704 modified "2023-09-25" @default.
- W4241155704 title "Chlorodibenzofurans (CDFs)" @default.
- W4241155704 doi "https://doi.org/10.1016/b978-0-12-386454-3.01113-1" @default.
- W4241155704 hasPublicationYear "2014" @default.
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