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- W4241159918 abstract "The present study underscores a regulatory role of intracellular ceramide in astrocytes for the release of an extracellular serine protease, tissue-type plasminogen activator (t-PA), and its inhibitor, plasminogen activator inhibitor-1 (PAI-1). Treatment of cultured human astrocytes with N-acetylsphingosine, a cell-permeable short-chain ceramide analogue or daunorubicin that could increase intracellular ceramide via activation of ceramide synthase or sphingomyelin hydrolysis increased the release of t-PA and conversely decreased the PAI-1 release. Interestingly, treatment of the astrocytes with tumor necrosis factor (TNF)-α also increased the intracellular ceramide levels but caused the elevation of PAI-1 release without altering the t-PA release. These data suggest that the generation of ceramide in astrocytes is linked at least with the regulation of PAI-1 release. We also demonstrate that the suppression of PAI-1 release with daunorubicin accelerates the cell death of neuronally differentiated PC12 cells and suggest an antiapoptotic role of PAI-1 in the nervous system. J. Neurosci. Res. 62:781–788, 2000. © 2000 Wiley-Liss, Inc." @default.
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- W4241159918 date "2000-12-15" @default.
- W4241159918 modified "2023-09-30" @default.
- W4241159918 title "Release of plasminogen activator inhibitor‐1 from human astrocytes is regulated by intracellular ceramide" @default.
- W4241159918 doi "https://doi.org/10.1002/1097-4547(20001215)62:6<781::aid-jnr4>3.3.co;2-n" @default.
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