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- W4241216093 abstract "We congratulate Takagi and colleagues on their updated meta-analysis comparing drug-eluting stent (DES) treatment with coronary artery bypass grafting (CABG) for patients with multivessel coronary artery disease. Our meta-analysis of trials (1 randomized, 24 nonrandomized) comparing CABG with DES treatment for multivessel coronary artery disease showed similar rates of all-cause mortality in the 2 groups but a lower incidence of major adverse cardiac and cerebrovascular events in the CABG group at 1 year and beyond.1Yan TD, Padang R, Poh C, Cao C, Wilson MK, Bannon PG, et al. Drug-eluting stents versus coronary artery bypass grafting for the treatment of coronary artery disease: a meta-analysis of randomized and nonrandomized studies. J Thorac Cardiovasc Surg. Epub 2010 Dec 16.Google Scholar The major contributor to the increased incidence of major adverse cardiac and cerebrovascular events seen in the DES group was the increased rate of repeat revascularization in that group. Unlike our meta-analysis, in which unadjusted hazard ratios from the observational studies were used, Takagi and colleagues’ analysis used adjusted hazard ratios to demonstrate significantly increased mortality in the DES group beyond 1 year. When trials including patients with 2-vessel disease and 3-vessel disease were pooled separately, no significant difference in mortality was seen. These studies provide further evidence that CABG remains the standard of care for patients with multivessel coronary artery disease. In the 3-year outcomes of the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) trial, presented at the 2010 European Association of Cardio-Thoracic Surgery meeting,2Kappetein AP; on behalf of the SYNTAX Investigators. 3-year Outcomes of the SYNTAX trial. In: Proceedings of the 24th Annual Meeting of the European Association of Cardio-Thoracic Surgeons; Sept 12, 2010; Geneva, Switzerland. Available at: http://www.syntaxscore.com/index.php?option=com_rubberdoc&view=doc&id=38&format=raw.Google Scholar the incidence of major adverse cardiac and cerebrovascular events remained significantly greater among patients undergoing percutaneous coronary intervention than among those undergoing CABG. This was a result of greater rates of both repeat revascularization and myocardial infarction beyond 1 year in the former group. Improvements in surgical revascularization are often overlooked. The main criticism of surgery in the SYNTAX trial (also shown in our meta-analysis) is the increased rate of perioperative stroke compared with percutaneous coronary intervention with DESs.1Yan TD, Padang R, Poh C, Cao C, Wilson MK, Bannon PG, et al. Drug-eluting stents versus coronary artery bypass grafting for the treatment of coronary artery disease: a meta-analysis of randomized and nonrandomized studies. J Thorac Cardiovasc Surg. Epub 2010 Dec 16.Google Scholar, 3Serruys P.W. Morice M.C. Kappetein A.P. Colombo A. Holmes D.R. Mack M.J. et al.Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease.N Engl J Med. 2009; 360: 961-972Crossref PubMed Scopus (3001) Google Scholar There has been renewed interest in off-pump CABG, ideally without manipulation of the ascending aorta, in an attempt to decrease the rate of perioperative stroke. We have recently published a meta-analysis comparing off-pump CABG with percutaneous coronary intervention 4Edelman J.J. Yan T.D. Padang R. Bannon P.G. Vallely M.P. Off-pump coronary artery bypass surgery versus percutaneous coronary intervention: a meta-analysis of randomized and nonrandomized studies.Ann Thorac Surg. 2010; 90: 1384-1390Abstract Full Text Full Text PDF PubMed Scopus (15) Google Scholar The results suggest equivalent rates of stroke for off-pump CABG and percutaneous coronary intervention (unlike the SYNTAX results) but significantly lower rates of major adverse cardiac and cerebrovascular events in the surgical group. Debate surrounding the relative graft patencies of conventional CABG and off-pump CABG is ongoing. There is evidence, however, that when performed by surgeons experienced in the technically demanding technique, off-pump CABG achieves a graft patency equivalent to that of CABG.5Angelini G.D. Culliford L. Smith D.K. Hamilton M.C. Murphy G.J. Ascione R. et al.Effects of on- and off-pump coronary artery surgery on graft patency, survival, and health-related quality of life: long-term follow-up of 2 randomized controlled trials.J Thorac Cardiovasc Surg. 2009; 137: 295-303Abstract Full Text Full Text PDF PubMed Scopus (141) Google Scholar, 6Puskas J.D. Williams W.H. Mahoney E.M. Huber P.R. Block P.C. Duke P.G. et al.Off-pump vs conventional coronary artery bypass grafting: early and 1-year graft patency, cost, and quality-of-life outcomes: a randomized trial.JAMA. 2004; 291: 1841-1849Crossref PubMed Scopus (464) Google Scholar The debate regarding CABG versus DES treatment is complex, and the goalposts are continually being shifted by evolving DES technology. This makes comparison of DES treatment with CABG difficult—perhaps indeed a Gordian knot in the question of myocardial revascularization. A solution, however, may not require the resurrection of Alexander the Great to cut the knot. Rather, well-constructed trials (such as SYNTAX) and then a combined approach to decision making involving both cardiologists and surgeons will ensure selection of the most appropriate intervention for each patient and ultimately the best outcome. The Gordian knot of revascularization for multivessel coronary artery diseaseThe Journal of Thoracic and Cardiovascular SurgeryVol. 142Issue 1PreviewTo the Editor: Full-Text PDF" @default.
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- W4241216093 date "2011-07-01" @default.
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- W4241216093 title "Reply to the Editor" @default.
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