Matches in SemOpenAlex for { <https://semopenalex.org/work/W4241219252> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4241219252 endingPage "230" @default.
- W4241219252 startingPage "221" @default.
- W4241219252 abstract "Potassium Chlorate is an inorganic salt that is intended for use in cosmetic ingredients as an oxidizing agent, but there are no current uses reported. Oral administration of Potassium Chlorate with 36 C label to rats produced elimination of the label as chloride, chlorate, and chlorite, in descending order of percentage. Potassium Chlorate causes mechanical fragility in erythrocytes and is a catalase inhibitor. In animals dosed orally with Potassium Chlorate, renal tubular necrosis has been seen. Only one mutagenicity study was available, the results of which were negative. A 6-month study in male rats of the tumor promotion potential of Potassium Chlorate caused no effect. Chlorate salts are considered toxic to humans with the lethal ingested dose estimated at 15 to 35 g. Toxic effects of lower doses in humans are seen in the kidneys, gastrointestinal tract, and blood (erythrocytes). Toxic effects in humans appear to be cumulative. The available data were insufficient to support the safety of this ingredient in cosmetic formulations. Additional data are considered necessary to evaluate the safety of this ingredient, including purpose of use and likely concentration of use in cosmetics, 28-day dermal toxicity data, ocular irritation data (if intended for use on or near the eye), two mutagenicity studies (if results are positive, carcinogenicity data are needed), human irritation data as a function of dose, and human sensitization data. It cannot be concluded that this ingredient is safe for use in cosmetic products until the listed safety data have been obtained and evaluated." @default.
- W4241219252 created "2022-05-12" @default.
- W4241219252 date "1995-06-01" @default.
- W4241219252 modified "2023-09-27" @default.
- W4241219252 title "Final Report on the Safety Assessment of Potassium Chlorate" @default.
- W4241219252 cites W1724659471 @default.
- W4241219252 cites W1963532759 @default.
- W4241219252 cites W1972983341 @default.
- W4241219252 cites W2007749440 @default.
- W4241219252 cites W2071746915 @default.
- W4241219252 cites W2091710487 @default.
- W4241219252 cites W2110875498 @default.
- W4241219252 cites W2236361025 @default.
- W4241219252 cites W2266051437 @default.
- W4241219252 cites W323883268 @default.
- W4241219252 cites W956987049 @default.
- W4241219252 doi "https://doi.org/10.3109/10915819509008698" @default.
- W4241219252 hasPublicationYear "1995" @default.
- W4241219252 type Work @default.
- W4241219252 citedByCount "16" @default.
- W4241219252 countsByYear W42412192522012 @default.
- W4241219252 countsByYear W42412192522013 @default.
- W4241219252 countsByYear W42412192522019 @default.
- W4241219252 crossrefType "journal-article" @default.
- W4241219252 hasConcept C178790620 @default.
- W4241219252 hasConcept C179104552 @default.
- W4241219252 hasConcept C185592680 @default.
- W4241219252 hasConcept C203014093 @default.
- W4241219252 hasConcept C2777063393 @default.
- W4241219252 hasConcept C2780399513 @default.
- W4241219252 hasConcept C29730261 @default.
- W4241219252 hasConcept C33070731 @default.
- W4241219252 hasConcept C517785266 @default.
- W4241219252 hasConcept C71924100 @default.
- W4241219252 hasConcept C86803240 @default.
- W4241219252 hasConcept C98274493 @default.
- W4241219252 hasConceptScore W4241219252C178790620 @default.
- W4241219252 hasConceptScore W4241219252C179104552 @default.
- W4241219252 hasConceptScore W4241219252C185592680 @default.
- W4241219252 hasConceptScore W4241219252C203014093 @default.
- W4241219252 hasConceptScore W4241219252C2777063393 @default.
- W4241219252 hasConceptScore W4241219252C2780399513 @default.
- W4241219252 hasConceptScore W4241219252C29730261 @default.
- W4241219252 hasConceptScore W4241219252C33070731 @default.
- W4241219252 hasConceptScore W4241219252C517785266 @default.
- W4241219252 hasConceptScore W4241219252C71924100 @default.
- W4241219252 hasConceptScore W4241219252C86803240 @default.
- W4241219252 hasConceptScore W4241219252C98274493 @default.
- W4241219252 hasIssue "3" @default.
- W4241219252 hasLocation W42412192521 @default.
- W4241219252 hasOpenAccess W4241219252 @default.
- W4241219252 hasPrimaryLocation W42412192521 @default.
- W4241219252 hasRelatedWork W1967661760 @default.
- W4241219252 hasRelatedWork W1977393998 @default.
- W4241219252 hasRelatedWork W1996664277 @default.
- W4241219252 hasRelatedWork W2073178845 @default.
- W4241219252 hasRelatedWork W2079460006 @default.
- W4241219252 hasRelatedWork W2362954041 @default.
- W4241219252 hasRelatedWork W2766473463 @default.
- W4241219252 hasRelatedWork W2952190333 @default.
- W4241219252 hasRelatedWork W3082151918 @default.
- W4241219252 hasRelatedWork W791954815 @default.
- W4241219252 hasVolume "14" @default.
- W4241219252 isParatext "false" @default.
- W4241219252 isRetracted "false" @default.
- W4241219252 workType "article" @default.