Matches in SemOpenAlex for { <https://semopenalex.org/work/W4241233276> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4241233276 endingPage "51" @default.
- W4241233276 startingPage "42" @default.
- W4241233276 abstract "The rat alpha 1-acid glycoprotein (AGP) gene is transcriptionally regulated by dexamethasone, interleukin 1 (IL-1), hepatocyte-stimulating factor, and beta 2 interferon. The steroid and peptide hormones stimulate expression of the AGP gene synergistically as well as independently. The regulatory sequence responsible for dexamethasone-stimulated expression has been localized previously to a region that is 120 to 64 base pairs (bp) upstream of the transcription start site (H. Baumann and L. E. Maquat, Mol. Cell. Biol. 6:2551-2561, 1986). To identify the regulatory sequence that is responsive to the peptide hormones, different lengths of the AGP gene 5'-flanking DNA were linked to the chloramphenicol acetyltransferase gene and then assayed for hormone-inducible chloramphenicol acetyltransferase gene expression in transiently transfected HepG2 cells. We demonstrate that an enhancer region that is responsive to IL-1, hepatocyte-stimulating factor, and beta 2 interferon lies within a 142-bp sequence located 5,300 to 5,150 bp upstream of the transcription start site. This distal regulatory region can confer hormone inducibility to a heterologous promoter; exert its affect in either orientation; and function, to a lesser degree, in nonhepatic but IL-1-responsive cells." @default.
- W4241233276 created "2022-05-12" @default.
- W4241233276 creator A5033429257 @default.
- W4241233276 creator A5070859823 @default.
- W4241233276 date "1988-01-01" @default.
- W4241233276 modified "2023-10-16" @default.
- W4241233276 title "Hepatocyte-stimulating factor, beta 2 interferon, and interleukin-1 enhance expression of the rat alpha 1-acid glycoprotein gene via a distal upstream regulatory region" @default.
- W4241233276 cites W102745621 @default.
- W4241233276 cites W1486833195 @default.
- W4241233276 cites W1496710035 @default.
- W4241233276 cites W1522050581 @default.
- W4241233276 cites W1541596961 @default.
- W4241233276 cites W1546727913 @default.
- W4241233276 cites W1558382061 @default.
- W4241233276 cites W1606423922 @default.
- W4241233276 cites W1636165650 @default.
- W4241233276 cites W1791967303 @default.
- W4241233276 cites W1908567109 @default.
- W4241233276 cites W193754658 @default.
- W4241233276 cites W1965372133 @default.
- W4241233276 cites W1976782468 @default.
- W4241233276 cites W1999912636 @default.
- W4241233276 cites W2002076761 @default.
- W4241233276 cites W2036452124 @default.
- W4241233276 cites W2055654988 @default.
- W4241233276 cites W2072585523 @default.
- W4241233276 cites W2075840772 @default.
- W4241233276 cites W2078233659 @default.
- W4241233276 cites W2084193227 @default.
- W4241233276 cites W2095184753 @default.
- W4241233276 cites W2126726439 @default.
- W4241233276 cites W2129787999 @default.
- W4241233276 cites W2144206181 @default.
- W4241233276 cites W2149563853 @default.
- W4241233276 cites W2246568657 @default.
- W4241233276 cites W4231386602 @default.
- W4241233276 cites W4253923417 @default.
- W4241233276 cites W94005661 @default.
- W4241233276 doi "https://doi.org/10.1128/mcb.8.1.42-51.1988" @default.
- W4241233276 hasPublicationYear "1988" @default.
- W4241233276 type Work @default.
- W4241233276 citedByCount "1" @default.
- W4241233276 crossrefType "journal-article" @default.
- W4241233276 hasAuthorship W4241233276A5033429257 @default.
- W4241233276 hasAuthorship W4241233276A5070859823 @default.
- W4241233276 hasConcept C101762097 @default.
- W4241233276 hasConcept C104317684 @default.
- W4241233276 hasConcept C111936080 @default.
- W4241233276 hasConcept C150194340 @default.
- W4241233276 hasConcept C153911025 @default.
- W4241233276 hasConcept C165864922 @default.
- W4241233276 hasConcept C21592294 @default.
- W4241233276 hasConcept C2780730277 @default.
- W4241233276 hasConcept C55493867 @default.
- W4241233276 hasConcept C86803240 @default.
- W4241233276 hasConceptScore W4241233276C101762097 @default.
- W4241233276 hasConceptScore W4241233276C104317684 @default.
- W4241233276 hasConceptScore W4241233276C111936080 @default.
- W4241233276 hasConceptScore W4241233276C150194340 @default.
- W4241233276 hasConceptScore W4241233276C153911025 @default.
- W4241233276 hasConceptScore W4241233276C165864922 @default.
- W4241233276 hasConceptScore W4241233276C21592294 @default.
- W4241233276 hasConceptScore W4241233276C2780730277 @default.
- W4241233276 hasConceptScore W4241233276C55493867 @default.
- W4241233276 hasConceptScore W4241233276C86803240 @default.
- W4241233276 hasIssue "1" @default.
- W4241233276 hasLocation W42412332761 @default.
- W4241233276 hasOpenAccess W4241233276 @default.
- W4241233276 hasPrimaryLocation W42412332761 @default.
- W4241233276 hasRelatedWork W1772150901 @default.
- W4241233276 hasRelatedWork W2024347625 @default.
- W4241233276 hasRelatedWork W2056422973 @default.
- W4241233276 hasRelatedWork W2115998171 @default.
- W4241233276 hasRelatedWork W2126789309 @default.
- W4241233276 hasRelatedWork W2131962335 @default.
- W4241233276 hasRelatedWork W2765063406 @default.
- W4241233276 hasRelatedWork W4223420578 @default.
- W4241233276 hasRelatedWork W4240789496 @default.
- W4241233276 hasRelatedWork W4256377748 @default.
- W4241233276 hasVolume "8" @default.
- W4241233276 isParatext "false" @default.
- W4241233276 isRetracted "false" @default.
- W4241233276 workType "article" @default.