Matches in SemOpenAlex for { <https://semopenalex.org/work/W4241234041> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4241234041 endingPage "18" @default.
- W4241234041 startingPage "1" @default.
- W4241234041 abstract "Summary Protein domains sometime combine to form multidomain proteins and are acquired or lost in lineages of organisms. These processes are ubiquitous in modern metabolism. To sort out evolutionary patterns of domain recruitment, we developed an algorithm that derives the most plausible ancestry of an enzyme from structural and evolutionary annotations in the MANET database. We applied this algorithm to the analysis of 1,163 enzymes with structural assignments. We then counted the number of enzymes along a time series and analyzed enzyme distribution in organisms belonging to superkingdoms Archaea, Bacteria, and Eukarya. The generated timelines described the evolution of modern metabolic networks and showed an early build-up of metabolic activities associated with metabolism of nucleotides, cofactors, and vitamins, followed by enzymes involved in carbohydrate and amino acid metabolism. More importantly, we find that existing domain structures were pervasively co-opted to perform more modern enzymatic tasks, either singly or in combination with other domains. This occurred differentially in lineages of the superkingdoms as the world diversified and organisms adapted to various environments. Our results highlight the important role of recruitment and domain organization in metabolic evolution." @default.
- W4241234041 created "2022-05-12" @default.
- W4241234041 creator A5019042699 @default.
- W4241234041 creator A5026404241 @default.
- W4241234041 creator A5080486194 @default.
- W4241234041 date "2013-03-01" @default.
- W4241234041 modified "2023-10-01" @default.
- W4241234041 title "Widespread Recruitment of Ancient Domain Structures in Modern Enzymes during Metabolic Evolution" @default.
- W4241234041 doi "https://doi.org/10.1515/jib-2013-214" @default.
- W4241234041 hasPublicationYear "2013" @default.
- W4241234041 type Work @default.
- W4241234041 citedByCount "4" @default.
- W4241234041 countsByYear W42412340412015 @default.
- W4241234041 countsByYear W42412340412016 @default.
- W4241234041 countsByYear W42412340412019 @default.
- W4241234041 countsByYear W42412340412023 @default.
- W4241234041 crossrefType "journal-article" @default.
- W4241234041 hasAuthorship W4241234041A5019042699 @default.
- W4241234041 hasAuthorship W4241234041A5026404241 @default.
- W4241234041 hasAuthorship W4241234041A5080486194 @default.
- W4241234041 hasBestOaLocation W42412340411 @default.
- W4241234041 hasConcept C101810790 @default.
- W4241234041 hasConcept C104317684 @default.
- W4241234041 hasConcept C134306372 @default.
- W4241234041 hasConcept C144292202 @default.
- W4241234041 hasConcept C166957645 @default.
- W4241234041 hasConcept C181199279 @default.
- W4241234041 hasConcept C188880781 @default.
- W4241234041 hasConcept C192989942 @default.
- W4241234041 hasConcept C197957613 @default.
- W4241234041 hasConcept C33923547 @default.
- W4241234041 hasConcept C36503486 @default.
- W4241234041 hasConcept C4438859 @default.
- W4241234041 hasConcept C523546767 @default.
- W4241234041 hasConcept C54355233 @default.
- W4241234041 hasConcept C550995028 @default.
- W4241234041 hasConcept C55493867 @default.
- W4241234041 hasConcept C70721500 @default.
- W4241234041 hasConcept C78458016 @default.
- W4241234041 hasConcept C86803240 @default.
- W4241234041 hasConcept C90132467 @default.
- W4241234041 hasConcept C95457728 @default.
- W4241234041 hasConceptScore W4241234041C101810790 @default.
- W4241234041 hasConceptScore W4241234041C104317684 @default.
- W4241234041 hasConceptScore W4241234041C134306372 @default.
- W4241234041 hasConceptScore W4241234041C144292202 @default.
- W4241234041 hasConceptScore W4241234041C166957645 @default.
- W4241234041 hasConceptScore W4241234041C181199279 @default.
- W4241234041 hasConceptScore W4241234041C188880781 @default.
- W4241234041 hasConceptScore W4241234041C192989942 @default.
- W4241234041 hasConceptScore W4241234041C197957613 @default.
- W4241234041 hasConceptScore W4241234041C33923547 @default.
- W4241234041 hasConceptScore W4241234041C36503486 @default.
- W4241234041 hasConceptScore W4241234041C4438859 @default.
- W4241234041 hasConceptScore W4241234041C523546767 @default.
- W4241234041 hasConceptScore W4241234041C54355233 @default.
- W4241234041 hasConceptScore W4241234041C550995028 @default.
- W4241234041 hasConceptScore W4241234041C55493867 @default.
- W4241234041 hasConceptScore W4241234041C70721500 @default.
- W4241234041 hasConceptScore W4241234041C78458016 @default.
- W4241234041 hasConceptScore W4241234041C86803240 @default.
- W4241234041 hasConceptScore W4241234041C90132467 @default.
- W4241234041 hasConceptScore W4241234041C95457728 @default.
- W4241234041 hasIssue "1" @default.
- W4241234041 hasLocation W42412340411 @default.
- W4241234041 hasOpenAccess W4241234041 @default.
- W4241234041 hasPrimaryLocation W42412340411 @default.
- W4241234041 hasRelatedWork W1493682653 @default.
- W4241234041 hasRelatedWork W2002468235 @default.
- W4241234041 hasRelatedWork W2084078493 @default.
- W4241234041 hasRelatedWork W2099264865 @default.
- W4241234041 hasRelatedWork W2127567371 @default.
- W4241234041 hasRelatedWork W2182260244 @default.
- W4241234041 hasRelatedWork W2560634075 @default.
- W4241234041 hasRelatedWork W2791826169 @default.
- W4241234041 hasRelatedWork W2806948486 @default.
- W4241234041 hasRelatedWork W4241234041 @default.
- W4241234041 hasVolume "10" @default.
- W4241234041 isParatext "false" @default.
- W4241234041 isRetracted "false" @default.
- W4241234041 workType "article" @default.