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- W4241349981 abstract "Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/vitamin B(12) 500 microg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo." @default.
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- W4241349981 date "2006-06-26" @default.
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- W4241349981 title "Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: A randomized controlled study" @default.
- W4241349981 doi "https://doi.org/10.1212/01.wnl.0000219815.83681.f7" @default.
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