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- W4241401467 abstract "The effect-kinetics of the new benzodiazepine midazolam was evaluated in six subjects after single oral (7.5 and 15 mg) and intravenous (0.075 mg/kg) doses and infusion programs. The drug is bound to plasma proteins by 94%, and less than 0.5% is excreted unchanged in urine. Hepatic elimination is rapid: t½β is 2.4 ± 0.8 hr (x̄ ± S.D.) and total body clearance is 283 ± 43 ml/min (plasma) or 502 ± 105 ml/min (blood). This substantial first-pass effect leads to bioavailability of only 44%, despite very rapid absorption (t½abs = 0.23 ± 0.37 hr) after oral dosing. There is good intraindividual linear correlations (r between 0.68 and 0.97) between plasma levels and dynamic effects, as assessed by the d2 letter cancellation test and a sedation index formed from visual analogue scales. Clinical Pharmacology and Therapeutics (1981) 30, 653–661; doi:10.1038/clpt.1981.217" @default.
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- W4241401467 date "1981-11-01" @default.
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- W4241401467 title "Midazolam kinetics" @default.
- W4241401467 doi "https://doi.org/10.1038/clpt.1981.217" @default.
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